Gupta, Bhushan VVerma, SohaniRaina, V PIravathy, Goud K2012-11-262012-11-262006-05Gupta Bhushan V, Verma Sohani, Raina V P, Iravathy Goud K. Lissencephaly child showing FISH negative and mutation in DCX gene with normal parental genetic makeup. Indian Journal of Human Genetics. 2006 May; 12(2): 93-95.http://imsear.searo.who.int/handle/123456789/143305Lissencephaly is a clinically and genetically heterogeneous malformation of the brain, leading to a severe disabling condition and seizures. The recent discovery of molecular techniques and identification of lissencephaly genes (LIS 1 and DCX) has allowed etiologic diagnosis of this disorder. We describe a patient with lissencephaly in whom fluorescence in situ hybridization and DCX mutation analysis determined etiologic diagnosis, allowing precise genetic counseling and providing prenatal diagnosis for the family.enDCX gene mutationlissencephalyMiller-Dieker syndromesmooth brainArticle