Sinha, SSahu, SPati, JRay, BPattnaik, SK2020-04-102020-04-102019-03Sinha S, Sahu S, Pati J, Ray B, Pattnaik SK. Retrospective analysis of colistin-resistant bacteria in a tertiary care centre in India. Indian Journal of Medical Research. 2019 Mar; 149(3): 418-4220971-59160975-9174http://imsear.searo.who.int/handle/123456789/195829The incidence of carbapenem-resistant Enterobacteriaceae has been steadily rising. The morbidity, mortality and financial implications of such patients are significant. We did a retrospective analysis of the case records of 11 patients who had culture report positive for pan drug-resistant (PDR) organisms. There were total 15 isolates of PDR organisms in 11 patients. These were associated with catheter-associated urinary tract infections (7), tracheitis (4), bacteraemia (2), meningitis (1) and soft-tissue infection (1). Average APACHE II score was 23.72 (range 7-36) indicating patients with multiple co-morbidities and organ dysfunction. The average length of hospital stay was 60.72 (25-123) days. The overall mortality rate was 81.81 per cent, while PDR infection-related mortality was 18.18 per cent. Strict implementation of antibiotic stewardship programme is essential to limit use and prevent abuse of colistin.Antibiotic abusecarbapenem resistancecolistinmortalitypan drug-resistanceJournal ArticleIndiaDepartment of Critical Care Medicine, Apollo Hospitals, Bhubaneswar, IndiaDepartment of Microbiology, Apollo Hospitals, Bhubaneswar, India