Laurent, DominiqueBaumann, FrancineBenoit, Anne GaelleMortelecqe, AlainNitatpattana, NarongDesvignes, IsabelleDebitus, CécileLaille, ManolaGonzalez, Jean-PaulChungue, Eliane2009-05-272009-05-272005-07-22Laurent D, Baumann F, Benoit AG, Mortelecqe A, Nitatpattana N, Desvignes I, Debitus C, Laille M, Gonzalez JP, Chungue E. Structure-activity relationships of dengue antiviral polycyclic quinones. The Southeast Asian Journal of Tropical Medicine and Public Health. 2005 Jul; 36(4): 901-5http://imsear.searo.who.int/handle/123456789/32284The Southeast Asian Journal of Tropical Medicine and Public Health.The virucidal and antiviral photoactivities of three compounds, hypericin, tetrabromohypericin and gymnochrome B, were evaluated against dengue viruses. All the three products were active, and both the virucidal and antiviral activities were enhanced by light. Gymnochrome B was more potent than hypericin and tetrabromohypericin. The presence of the side chains on the hypericin core of gymnochromes appears to be beneficial for both virucidal and antiviral activities. This enhanced activity is likely to be linked to a complementary mechanism independent of photoactivation.engAnimalsDengue VirusMolecular StructurePolycyclic Hydrocarbons, AromaticQuinonesStructure-Activity RelationshipJournal Article