Gupta, SDutta, G PVishwakarma, R A2009-05-282009-05-281998-08-05Gupta S, Dutta GP, Vishwakarma RA. Effect of alpha,beta-arteether against primary amoebic meningoencephalitis in Swiss mice. Indian Journal of Experimental Biology. 1998 Aug; 36(8): 824-5http://imsear.searo.who.int/handle/123456789/61193Artemisinin and its derivative alpha, beta-arteether have been evaluated for activity against experimental primary amoebic meningoencephalitis. In vivo experiments have shown that amphotericin B at dose of 2.5 mg/kg for 5 days produced 100% protection. Artemisinin and alpha, beta-arteether, even when tested at a high doses (60-120 mg/kg x 5 days and 90-180 mg/x 5 days) respectively, were not curative and showed only slight protection as indicated by extension of mean survival time.engAmebiasis --drug therapyAmebicides --administration & dosageAmphotericin B --administration & dosageAnimalsArtemisininsMeningoencephalitis --drug therapyMiceNaegleria fowleri --isolation & purificationSesquiterpenes --administration & dosageComparative Study