Stabile, SFranchina, VTestoni, SMannozzi, FFabbri, FFederici, IBetti, MZepponi, FFrazzetto, AMicallo, GBertolotti, RSangalli, CCagnazzo, CNanni, O.2025-05-092025-05-092024-09Stabile S, Franchina V, Testoni S, Mannozzi F, Fabbri F, Federici I, Betti M, Zepponi F, Frazzetto A, Micallo G, Bertolotti R, Sangalli C, Cagnazzo C, Nanni O.. Perception of decentralized clinical trials and home nursing in oncology clinical research: insights from a survey of clinical research professionals across experimental sites . International Journal of Clinical Trials. 2024 Sep; 11(3): 162-1692349-32402349-3259https://imsear.searo.who.int/handle/123456789/243644Background: Post-COVID-19, rapid technological progress enabled remote healthcare interactions, fostering DCT activities. Sponsors and sites adapted by digitizing traditional model, utilizing wearables and home nursing. However, challenges like staff oversight and logistics demand careful evaluation for regulatory compliance. Methods: Italian association of medical oncology's study coordinators working group, in collaboration with Italian group of data managers, conducted an anonymous online survey among Italian oncology professionals. Survey aimed to explore their perceptions of remote patient monitoring, trial activities, and home nursing in oncology clinical trials. Results: Out of 111 professionals (42.3% coordinators, 27.0% physicians, 18.8% nurses), 29.7% lacked prior experience in remote patient data capture, while 61.3% had low or medium experience. On a 0-10 VAS scale, 58.6% found remote modalities very useful, with high scores (8-10) for various remote activities like quality of life data capture (71.2%), vital signs transmission (66.7%), and home nursing tasks (65.8%). Regarding home nursing in oncology clinical trials 73.0% of participants (n=81) have declared no previous experience. However this remote activity is considered highly useful for tasks such as biological samples collection (76.6%), vital signs collection (73.9%), quality of life evaluation (71.2%), and adverse events monitoring (65.8%). Conclusions: Electronic devices for remote data capture are prevalent in oncology trials, positively perceived by a significant portion of staff. Remote data collection correlates with improved workload perception. Although home nursing is less common in Italy, healthcare professionals show a positive perception, indicating potential benefits for clinical trial efficiency and workload improvement.Decentralized clinical trialsHome nursingClinical researchOncologyJournal ArticleIndiaSC Oncologia Falck, Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milano, ItalyU.O.C. Oncologia Medica A.O. Papardo, MessinaUnità di Biostatistica e Sperimentazioni Cliniche, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, ItalyUnità di Biostatistica e Sperimentazioni Cliniche, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, ItalyUnità di Biostatistica e Sperimentazioni Cliniche, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, ItalyClinica di Ematologia, AOU Ospedali Riuniti Umberto I, G.M. Lancisi, G. Salesi, Ancona, ItalyDipartimento Attività Integrate Ricerca Innovazione, AO SS. Antonio e Biagio e Cesare Arrigo, AlessandriaSOD Oncologia Clinica, Azienda Ospedaliero-Universitaria Careggi, FirenzeFarmacia Clinica, Fondazione Policlinico Tor Vergata, RomaDipartimento di Ricerca e Assistenziale di OncoEmatologia, Neoplasie Mesenchimali e Muscolo Scheletriche dell'Adulto e Diagnostica Innovativa Istituto Nazionale Tumori - Fondazione “G. Pascale”, NapoliData Management, Clinical Trial Office, European Institute of Oncology IRCCS, Milan, ItalyData Management, Clinical Trial Office, European Institute of Oncology IRCCS, Milan, ItalyDipartimento Patologia e Cura del Bambino, Regina Margherita AOU Città della Salute e della Scienza di Torino, Presidio Infantile Regina Margherita, Turin, ItalyUnità di Biostatistica e Sperimentazioni Cliniche, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy