B. R., B.Damle, H.Ganju, S.Damle, L.2020-09-242020-09-242020-08B. R. B., Damle H., Ganju S., Damle L.. Phytochemical To Interact With Nls Binding Site On Ima3 To Inhibit Importin Α/Β1 Mediated Nuclear Import Of Sars-Cov-2 Cargo. International Journal of Pharmacy and Pharmaceutical Sciences. 2020 Aug; 12(8): 30-350975-14912656-0097http://imsear.searo.who.int/handle/123456789/205993Objective: Ivermectin is an FDA-approved, broad-spectrum anti-parasitic agent. It was originally identified as an inhibitor of interaction between the human 29 immunodeficiency virus-1 (HIV-1) integrase protein (IN) and the Importin (IMP) α/β1 30 heterodimers, which are responsible for IN nuclear import. Recent studies demonstrate that ivermectin is worthy of further consideration as a possible SARS-CoV-2 antiviral. Methods: We built the pathogen-host interactome and analyzed it using PHISTO. We compared Ivermectin and plant molecules for their interaction with Importin α3 (IMA3) using molecular docking studies. Results: A phytochemical ATRI001 with the lowest binding energy-7.290 Kcal/mol was found to be superior to Ivermectin with binding energy-4.946 Kcal/mol. Conclusion: ATRI001 may be a potential anti-SARS-CoV-2 agent; however, it requires clinical evaluation.IvermectinSARS-CoV-2IMA3Phytochemical and Molecular dockingJournal ArticleIndiaAtrimed Biotech LLP, BBC, Electronics City Phase 1, Electronic City, Bengaluru, Karnataka 560100Atrimed Pharmaceuticals Pvt. Ltd. 14th Floor no 29, Prestige Meridian Tower 2, 30, Mahatma Gandhi Rd, KG Halli, D' Souza Layout, Ashok Nagar, Bengaluru, Karnataka 560001Atrimed Pharmaceuticals Pvt. Ltd. 14th Floor no 29, Prestige Meridian Tower 2, 30, Mahatma Gandhi Rd, KG Halli, D' Souza Layout, Ashok Nagar, Bengaluru, Karnataka 560001Atrimed Biotech LLP, BBC, Electronics City Phase 1, Electronic City, Bengaluru, Karnataka 560100