Sethi, P D1976-10-012009-06-011976-10-012009-06-011976-10-01Sethi PD. Antagonism of anthracene-9-carboxylic acid as screening test for muscle relaxants. Indian Journal of Physiology and Pharmacology. 1976 Oct-Dec; 20(4): 239-41http://imsear.searo.who.int/handle/123456789/107381Veratrinic response produced by anthracene-9-carboxylic acid in mice has been used as a model for studying effect of variety of drugs which induce muscle relaxation. None of the drugs listed as general depressants, central muscle relaxants, neuromuscular blocking agents and anti-convulsants were effective even at doses causing 100% loss of righting reflex. Local anaesthetics/direct acting muscle relaxants were effective. This simple model employed in conjunction with Straub's tail test can differentiate various categories of muscle relaxants and their mechanism of action.engAnesthetics, Local --pharmacologyAnimalsAnthracenes --antagonists & inhibitorsCarboxylic Acids --antagonists & inhibitorsDrug Evaluation, PreclinicalMiceMuscle Contraction --drug effectsMuscle Relaxation --drug effectsJournal Article