Sahu, DRanjan, VThakur, NRai, SKRao, MV.2023-08-192023-08-192022-06Sahu D, Ranjan V, Thakur N, Rai SK, Rao MV. . Assessment of Effectiveness of Targeted Intervention Program Under National AIDS Control Program among Injecting Drug Users Across India. Indian Journal of Public Health. 2023 Jun; 67(2): 247-2530019-557X2229-7693http://imsear.searo.who.int/handle/123456789/223919Background: High HIV prevalence among injecting drug users (IDUs) remains a cause of concern and are considered key drivers of concentrated epidemic in India. The present paper aims to assess the effectiveness of the targeted intervention (TI) program on the risk behaviors among IDUs across regions of India. Materials and Methods: This paper used the data from the integrated biological and behavioral surveillance 2014–2015 among the IDUs in India. Descriptive statistics and propensity score matching analysis was carried out to understand the effectiveness of the TI program on the new needle/syringe used and needle/syringe shared in the last injecting episode by accounting for the covariates. Results: The matched samples estimate, i.e., average treatment effect on treated of new needles/syringe used and shared in the last injecting episode by those who received needles/syringes from peer educator or outreach workers (PE/ORWs) and those who did not receive was 2.8% (confidence interval [CI]: 0.05–5.6) increase in the use of new needles/syringes and 6.5% (CI: −9.7–−3.3) decrease in the needles/syringes shared in last injecting episode indicating that IDUs who received new needles/syringes from PE/ORWs are more likely to use new needle/syringe and less likely to share needle/syringes to those who did not receive needles/syringes. The results vary across the different regions of India. Conclusion: TI program proves to be an effective initiative in the behavior change among IDUs as substantiated by use of new needles/syringes and decreased sharing of needles/syringes. TI program coverage varies from region to region and may further be expanded to accelerate the program services to prevent HIV/AIDS.Evaluationinjecting drug usersintegrated biological and behavioral surveypropensity score matchingtargeted interventionsJournal ArticleIndiaScientist FResearch OfficerPhD ScholarProfessor, Centre for Community Medicine, All India Institute of Medical Sciences, New Delhi, IndiaScientist G and Director, ICMR-National Institute of Medical Statistics