Nandeesha, HSathiyapriya, VBobby, ZachariahPavithran, PAgrawal, AparnaSelvaraj, N2007-06-152009-05-292007-06-152009-05-292007-06-15Nandeesha H, Sathiyapriya V, Bobby Z, Pavithran P, Agrawal A, Selvaraj N. Altered oxidant-antioxidant status in non-obese men with moderate essential hypertension. Indian Journal of Medical Sciences. 2007 Jun; 61(6): 326-31http://imsear.searo.who.int/handle/123456789/68521BACKGROUND: Although a wide number of experimental evidences are available regarding oxidant-antioxidant disturbance in hypertension, clinical data supporting it is lacking in men in early stages of hypertension. AIMS: The objective of the study was to evaluate oxidative status and antioxidant activities in males with stage I essential hypertension. MATERIALS AND METHODS: Thirty hypertensives and 21 normotensives were included in the study. Protein carbonyl, reduced glutathione, glutathione peroxidase, catalase and fasting glucose were assessed in both the groups. STATISTICAL ANALYSIS: Results were analyzed by student's 't' test and linear regression analysis test. RESULTS: Plasma protein carbonyl and glutathione peroxidase were significantly increased and catalase and GSH were significantly reduced in the hypertensive group compared to normotensive subjects. There was a significant negative correlation between glutathione peroxidase and catalase in the test group. CONCLUSIONS: The data from the present study indicates an alteration in oxidant-antioxidant status in non-obese men in early stages of essential hypertension.engAdultAntioxidants --metabolismBlood Glucose --metabolismCatalase --bloodGlutathione --bloodGlutathione Peroxidase --bloodHumansHypertension --bloodLinear ModelsMaleObesityOxidative StressProtein CarbonylationSeverity of Illness IndexJournal Article