Sen, SHabibuddin, MPal, S P2009-05-282009-05-281994-10-01Sen S, Habibuddin M, Pal SP. Antinociceptive action of N-octanoyl GABA--a new GABA mimetic agent. Indian Journal of Experimental Biology. 1994 Oct; 32(10): 718-23http://imsear.searo.who.int/handle/123456789/63040A new derivative of gamma-aminobutyric acid (GABA) was synthesized. The compound, N-octanoyl GABA (O-GABA), exhibited positive analgesic response in four different models in mice--tail immersion, hot plate, tail clip and acetic acid induced writhing. The antinociceptive activity was significantly blocked by picrotoxin but not by bicuculline or 3-mercaptopropionic acid. Naloxone failed to reverse the antinociceptive response of O-GABA but a synergistic action was observed with pethidine. Pretreatment with atropine significantly reduced the antinociceptive action of O-GABA. Biochemical tests revealed that O-GABA significantly increased brain GABA levels.engAnalgesics --pharmacologyAnimalsDrug Evaluation, PreclinicalGABA Agonists --pharmacologyMaleMicegamma-Aminobutyric Acid --analogs & derivativesJournal Article