Uppin, Megha SPaul, T RoshniRajappa, SenthilGayathri, KJacob, RachelUppin, Shantveer G2007-07-222009-05-292007-07-222009-05-292007-07-22Uppin MS, Paul TR, Rajappa S, Gayathri K, Jacob R, Uppin SG. Leukemia as a second malignancy. Indian Journal of Pathology & Microbiology. 2007 Jul; 50(3): 644-7http://imsear.searo.who.int/handle/123456789/72775To study the occurrence of leukemia as a second malignancy following various primary solid and hematological malignancies. Total 11 cases of leukemia presenting as a second malignancy were studied over a period of 15 years from 1990 to 2005. The primary malignancies included carcinoma breast (4), multiple myeloma (3) and one each of Hodgkin's lymphoma, mediastinal germ cell tumor, papillary carcinoma thyroid and myxopapillary ependymoma. Ten patients had received chemotherapy with combination radiotherapy in six patients. The commonest type of leukemia was AML-M2. The cyogenetic test results were available in three cases. The secondary leukemia showed aggressive behaviour and all patients on follow-up died within a period of one month. The risk benefit ratio of chemotherapy and radiotherapy should be considered before starting the patients on treatment. A high degree of suspicion and follow up with hematological parameters is required for therapy related complications.engAdultAntineoplastic Agents --adverse effectsCombined Modality TherapyFemaleHumansLeukemia, Myeloid, Acute --epidemiologyMaleMiddle AgedNeoplasms --therapyNeoplasms, Second Primary --epidemiologyRadiotherapy --adverse effectsJournal Article