Achliya, Girish SWadodkar, Sudhir GAvinash, K Dorle2009-05-282009-05-282004-05-06Achliya GS, Wadodkar SG, Avinash KD. Neuropharmacological actions of panchagavya formulation containing Emblica officinalis Gaerth and Glycyrrhiza glabra Linn in mice. Indian Journal of Experimental Biology. 2004 May; 42(5): 499-503http://imsear.searo.who.int/handle/123456789/62155A panchagavya Ayurvedic formulation containing E. officinalis, G. glabra, and cow's ghee was evaluated for its effect on pentobarbital-induced sleeping time, pentylenetetrazol-induced seizures, maximal electroshock-induced seizures, spontaneous motor activity, rota-rod performance (motor coordination) and antagonism to amphetamine in mice. The formulation (300, 500 mg/kg, po) produced a significant prolongation of pentobarbital-induced sleeping time and reduced spontaneous locomotor activity. The formulation also significantly antagonised the amphetamine induced hyper-locomotor activity (500, 750 mg/kg, po) and protected mice against tonic convulsions induced by maximal electroshock (500, 750 mg/kg, po). The formulation slightly prolonged the phases of seizure activity but did not protect mice against lethality induced by pentylenetetrazole. The formulation did not show neurotoxicity. The results suggest that the panchagavya formulation is sedative in nature.engAmphetamines --metabolismAnimalsAnticonvulsants --pharmacologyCattleDietary Fats --metabolismDose-Response Relationship, DrugElectroshockGlycyrrhiza --metabolismHypnotics and Sedatives --pharmacologyMiceMotor Activity --drug effectsPentobarbital --pharmacologyPentylenetetrazole --pharmacologyPhyllanthus emblica --metabolismSleep --drug effectsTime FactorsJournal Article