Güngör, ŞuleBahçetepe, NilgünTopal, İlteriş2015-01-072015-01-072014-01Güngör Şule, Bahçetepe Nilgün, Topal İlteriş. Removal of corns by punch incision: A retrospective analysis of 15 patients. Indian Journal of Dermatology, Venereology and Leprology. 2014 Jan-Feb; 80(1): 41-43.http://imsear.searo.who.int/handle/123456789/154744Background: Macrolides are prescribed in the treatment of pityriasis rosea despite conflicting results of the limited number of studies evaluating their role in its treatment. Aim: A randomized double-blind placebo-controlled trial was conducted to evaluate the effect of azithromycin on the clinical course of pityriasis rosea. Methods: Seventy patients of pityriasis rosea were given either azithromycin (n = 35) or placebo (n = 35) and were followed-up at 2, 4 and 6 weeks. Pruritus was assessed in both groups using the visual analogue scale (VAS) . Change in the pityriasis rosea severity score (PRSS) and in the VAS were recorded as outcome measures and were compared statistically. Results: The decrease in PRSS from baseline through 2, 4 and 6 weeks within both treatment (P < 0.001) and placebo (P < 0.001) arms was found to be statistically significant; however, this change was not significantly different in the two groups (P = 0.179). Similarly, the decrease in VAS was found to be statistically significant within both groups (P < 0.001); however, the change was comparable between the two groups (P < 0.937). Analysis by Fisher's exact test did not find a significant difference between the two groups for PRSS and VAS. Conclusion: Azithromycin is not effective in pityriasis rosea and the use of macrolides for this disease should not be encouraged in clinical practice.enAzithromycinpityriasis roseapityriasis rosea severity scorevisual analogue scaleAzithromycin --administration & dosageCallosities --surgeryHumansMinimally Invasive Surgical Procedures --methodsPityriasis RoseaSeverity of Illness IndexVisual Analog ScaleArticle