Dhabarde, MadhuriTirpude, Naresh G.2020-01-022020-01-022019-09Dhabarde Madhuri, Tirpude Naresh G.. Comparing the Effects of Different Volumes of 05% Hyperbaric Bupivacaine in Subarachnoid Blockade. Annals of International medical and Dental Research. 2019 Sep; 5(5): 19-222395-28222395-2814http://imsear.searo.who.int/handle/123456789/189070Spinal subarachnoid block is a preferred alternative to general anesthesia. We aimed to evaluate the anesthetic effect of different volumes of intrathecal administration of 0.5% bupivacaine in 8% dextrose and effect on hemodynamic parameters of the patient. Methods: This study was performed in the Department of Anesthesiology, DY Patil School of Medicine, Navi Mumbai from January 2014 till January 2015. We divided 75 patients, of American Society of Anaesthesiologists' (ASA) grade I and II, in to three groups, and received 2ml, 3 ml and 4 ml of 0.5% heavy bupivacaine with 8% glucose in the subarachnoid space respectively. The onset of anesthesia was noted, maximum height of analgesia, onset of motor block, degree of motor block and the maximum time required to obtain motor blockade was observed every two minutes. Hemodynamic parameters like pulse and systolic blood pressure were recorded. Results: All three groups had onset of anesthesia between 2 to 3 minutes and the difference of onset between the three groups was insignificant. There was no difference between the three groups with regards to time to attain maximum height of anesthesia and duration of two segment regression of sensory blockage. Increasing volume of bupivacaine was associated with increasing mean duration of complete sensory regression and complete motor blockade. There was a significant fall in systolic blood pressure 15 minutes after spinal block. Conclusion: Total duration of analgesia and motor blockade was noted with noted with higher volumes of bupivacaine. Higher hemodynamic instability was observed with higher volumes of hyperbaric bupivacaine. Future studies are needed to support our findings.spinal anesthesiabupivacaineoutcomesJournal ArticleIndiaAssociate Professor, Department of Anesthesiology, Terna Medical College and Hospital, Nerul, Navi Mumbai.Professor and Head, Department of Anesthesiology, Government Medical College, Nagpur.