Biswas, N MGhosh, P K2009-05-282009-05-282006-04-08Biswas NM, Ghosh PK. Protection of adrenal and male gonadal functions by androgen in lead-treated rats. Kathmandu University Medical Journal. 2006 Apr-Jun; 4(2): 218-21http://imsear.searo.who.int/handle/123456789/46576Kathmandu University Medical Journal.The potential health hazard of the large amounts of Lead that occurs in canned baby food, domestic water from lead-lined tanks and, in printing and petroleum industries. Lead acetate administration at a does of 8 mg/kg body weight for 21 days resulted a significant increase in adrenal steroidogenic enzyme (Delta5-3beta- HSD) and serum levels of corticosterone, while serum levels of testosterone, FSH, LH and testicular spermatogenesis were decreased in albino rats. But lead-treated rats received exogenous testosterone for the last 14 days of lead treatment, showed prevention of adrenocortical hyperactivity by decreasing adrenal Delta5-3beta-HSD activity and serum level of corticosterone. Testosterone administration also increased serum level of testosterone, FSH and LH along with spermatogenesis. The results suggest that testosterone supplementation in lead-treated rats protects adrenocortical activity and testicular spermatogenesis.engAdrenal Cortex --drug effectsAndrogens --bloodAnimalsCorticosterone --bloodFollicle Stimulating Hormone --bloodGenitalia, Male --drug effectsLead Poisoning --drug therapyMaleOrgan Size --drug effectsRatsSpermatogenesis --drug effectsTestosterone --bloodJournal Article