Khan, Muhammad Abdul HalimUddin, Md. FaridHasanat, M. A.Naznin, JobaidaDhar, Ashim2023-07-212023-07-212022-02Khan Muhammad Abdul Halim, Uddin Md. Farid, Hasanat M. A., Naznin Jobaida, Dhar Ashim. Determination of Serum Thyroglobulin Concentration in Simple Diffuse Goiter Patients with Known Iodine Status. Annals of International Medical and Dental Research. 2022 Feb; 8(1): 358-3672395-28222395-2814http://imsear.searo.who.int/handle/123456789/219931Background: Thyroglobulin (TG) seems to be a valuable indicator of thyroid function and iodine nutrition status. Aim of the study: The aim of the study was to observe the relationship between serum thyroglobulin and urinary iodine (UI) in simple diffuse goiter patients.Methods:This cross-sectional observational study was conducted at the Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. The study duration was 2 years, starting from May 2014 to March 2016. Total 87 patients with simple diffuse goiter attending the OPD Department of Endocrinology of BSMMU had been recruited as study population. A purposive sampling technique was followed for sample selection.Results:Serum thyroglobulin (ng/mL, mean盨D and median) was lowest in the age group 12-16 years (6.0�5, 5.16 ng/mL) followed by age>31 years (8.8�1, 6.16 ng/mL), whereas other age groups showed level around 13.0 and 10.0 ng/mL (p= 0.520). Mean (盨D) Urinary Iodine was not statistically different among age groups (347.4� 226.5 vs. 337.08�8.9 vs. 300.5� 95.37 vs. 337.7� 225.42 vs. 278.3� 105.7, 礸/L; F 0.451, p=0.771) while median values were 325.26 vs. 355.68 vs. 325.80 vs. 338.86 and 300.90 礸/L respectively. Neither thyroglobulin (5.76�72 vs. 11.60� 13.50; 3.47 vs. 8.9 ng/mL, m盨D and median; p=0.294) nor Urinary Iodine (373.5� 44.5 vs. 317.2� 180.32; 378.1 vs. 308.9 礸/L, m盨D and median; p=0.450) were statistically different between the gender groups. Similarly, thyroglobulin and Urinary Iodine were also statistically similar for grade-1 and grade-2 goiter (thyroglobulin: 6.79�33 vs. 11.67�.69 and 6.74 vs. 8.02 ng/mL, m盨D and median, p=0.319; Urinary Iodine: 361.33� 51.60 vs. 317.09� 182.44, 362.69 vs. 305.35 礸/L, m盨D and median, p=0.498).Conclusion:Thyroglobulin seems to have an inverse association in iodine deficiency state and positive association in over sufficient state with UI. There was no statistically significant difference of TG concentration between males and females nor between Grade-1 and Grade-2 goiter.GoiterDiffuseThyroglobulinIodineDeficiency.Journal ArticleIndiaAssistant Professor, Department of Endocrinology, Shaheed Suharawardy Medical College & Hospital, Dhaka, Bangladesh. Email: dr.mahalimkhan@gmail.com Orcid ID: 0000-0002-3459-2708Professor, Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. Email: dr.md.fariduddin@gmail.com Orcid ID: 0000-0002-7537-0933Professor, Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. Email: hasnat_endro@bsmmu.edu.bd Orcid ID: 0000-0001-8151-9792Assistant Professor, Department of Endocrinology, Shaheed Suharawardy Medical College & Hospital, Dhaka, Bangladesh. Email: urmi512@gmail.com Orcid ID: 0000-0002-0944-0593Medical Officer, Department of Endocrinology, Shaheed Suharawardy Medical College & Hospital, Dhaka, Bangladesh. Email: ashimcda@gmail.com Orcid ID: 0000-0002-6837-0089