Banerjee, SarmisthaDas, Sukta2009-05-272009-05-272005-07-21Banerjee S, Das S. Anticarcinogenic effects of an aqueous infusion of cloves on skin carcinogenesis. Asian Pacific Journal of Cancer Prevention. 2005 Jul-Sep; 6(3): 304-8http://imsear.searo.who.int/handle/123456789/38067Asian Pacific Journal of Cancer Prevention.Spices and flavouring agents are now receiving increasing attention as many of them have been shown to have anticarcinogenic properties. Cloves, sun-dried unopened flower buds from the plant Syzygium aromaticum L, are commonly used as a spice and food flavour. The present study was designed to investigate the chemopreventive action of aqueous infusion of cloves on 9,10-dimethyl benz(a)anthracene (DMBA) and croton oil induced skin carcinogenesis in Swiss mice. The results indicate protection against skin papilloma formation in a dose dependent manner. It has been shown that oral administration of aqueous infusions of clove at a dose of 100 microl/mouse/day not only delays the formation of papilloma but also reduces the incidence of papilloma as well as the cumulative number of papillomas per papilloma bearing mouse. Our observations suggest a promising role for cloves in restriction of the carcinogenesis process.eng9,10-Dimethyl-1,2-benzanthraceneAdministration, OralAnimalsCarcinogensCell Transformation, Neoplastic --drug effectsChemopreventionEugenia --chemistryMiceNeoplasms, ExperimentalPapilloma --physiopathologyPlant Extracts --pharmacologySkin Neoplasms --physiopathologyJournal Article