Rani, MeenuYadav, ShaileshChoudhary, SeemaSharma, SeemaPandey, Surya Mani2014-12-172014-12-172014-01Rani Meenu, Yadav Shailesh, Choudhary Seema, Sharma Seema, Pandey Surya Mani. Effect of glimepiride compared with glibenclamide on post prandial blood sugar in type II diabetes mellitus patients. International Journal of Basic & Clinical Pharmacology. 2014 Jan-Feb; 3(1): 96-99.http://imsear.searo.who.int/handle/123456789/154005Background: Diabetes mellitus is a major public health problem with many complications. The Global Burden of Diabetes Study has projected that there will be a 122% increase in the number of people with diabetes mellitus worldwide in 2025 compared to 1995. Despite the availability of new agents for the treatment of type 2 diabetes mellitus oral sulfonylureas remain a cornerstone of therapy. Glibenclamide and glimepiride are widely used sulfonylurea antidiabetic drugs. Methods: A randomized, open, parallel group study was conducted by the Department of Pharmacology in association with Department of Medicine at Maharishi Markandeshwar Institute of Medical Sciences & Research (MMIMSR), Mullana, Ambala. Total 50 patients were divided into two groups I & II. In Group I (n=25) glibenclamide (5-15 mg/day) & in Group II (n=25) glimepiride (1-6mg/day) was administered for a period of 24 weeks and data analyzed by Student’s “t”- test. Results: There was a significant improvement in the post prandial blood sugar score (p<0.05) in both the study groups (I&II) after 24 weeks but post prandial blood level did not differ significantly (p>0.05) between the two groups. Conclusions: Both the drugs glibenclamide and glimepiride were effectively reduced post prandial blood sugar in both the groups. But these sulfonylurea drugs lowered post prandial blood sugar to a similar degree without significant difference between the two groups.enType II diabetes mellitusGlimepirideGlibenclamidePost prandial blood sugarSulfonylureasArticle