Constance, NwadikeIjeoma, Nosiri ChidiAdindu, EzeChimaraoke, OnyeaboSunday, Ezekwe AhamefulaCatherine, Onyejiekwe2020-04-092020-04-092019Constance Nwadike, Ijeoma Nosiri Chidi, Adindu Eze, Chimaraoke Onyeabo, Sunday Ezekwe Ahamefula, Catherine Onyejiekwe. Serum Electrolytes and Red Blood Cell Membrane Potential of Hypertensive Patients. International Blood Research & Reviews. 2019; 10(1): 1-72321-7219http://imsear.searo.who.int/handle/123456789/192760Serum electrolyte and red blood cell membrane potential of hypertensive patients in Owerri metropolis were investigated. A total of 50 volunteer subjects were used for the study. Thirty (30) of the volunteer subjects were hypertensive subjects and were used as test subjects; while the remaining 20 subjects were healthy subjects with normal blood pressure used as normentensive subjects (control). Results observed showed increased red blood cell (RBC) K+ and Cl- in hypertension subjects against normentensive subjects. Apart from K+ which reduced significantly (p<0.05), other electrolyte ions of the serum increased significantly (p<0.05) in hypertensive subjects against normentensive subjects. However, Na+ and Cl- membrane potential was not significantly (p>0.05) altered in hypertensive subjects against normotensive subjects while K+ was significantly (p<0.05) altered. The observed alterations in the parameters investigated in hypertensive subjects in the present study could be as a result of a host of derangements involving electrolyte metabolism, altered membrane transport and a possible increase in membrane fragility. This study has shown the serum electrolyte and red blood cell membrane potential of hypertensive patients in Owerri metropolis.Electrolytehypertensive patientsmembrane potentialred blood cellJournal ArticleIndiaDepartment of Medical Laboratory Science, Imo State University, Owerri, Nigeria.Department of Biochemistry, Abia State University, Uturu, Nigeria.Department of Biochemistry, University of Calabar, Calabar, Nigeria.Department of Biochemistry, Michael Okpara University of Agriculture, Umudike, Nigeria.Department of Medical Biochemistry, Imo State University, Owerri, Nigeria.Department of Biochemistry, University of Lagos, Nigeria.