Amos, SBinda, LChindo, BAkah, PAbdurahman, MDanmallam, H UWambebe, CGamaniel, K2009-05-282009-05-282001-01-15Amos S, Binda L, Chindo B, Akah P, Abdurahman M, Danmallam HU, Wambebe C, Gamaniel K. Evaluation of methanolic extract of Ficus platyphylla on gastrointestinal activity. Indian Journal of Experimental Biology. 2001 Jan; 39(1): 63-7http://imsear.searo.who.int/handle/123456789/57938Methanolic extract of Ficus platyphylla was tested on isolated rabbit jejunum, rat duodenum and gastrointestinal motility in mice. The extract showed a biphasic effect on isolated smooth muscle. Lower concentration of extract caused contraction, while higher concentrations produced relaxation. The contractile phase was attenuated by atropine, while relaxant phase attenuated histamine induced contraction of guinea pig ileum. The extract also exhibited a dose-dependent inhibition of gastrointestinal motility. Acute toxicity test in mice established LD50 value (i.p.) of the extract to be 2000 mg/kg. Preliminary phytochemical screening of the extract gave positive test for flavonoids, tannins and saponins.engAnimalsDigestive System --drug effectsDose-Response Relationship, DrugFemaleGastrointestinal Transit --drug effectsGuinea PigsLethal Dose 50MaleMicePlant Extracts --pharmacologyRabbitsRatsRats, WistarRosales --chemistryEvaluation Studies