Thaw ZinMay Aye ThanTin Tin LayCho ChoTin OhnTin Mi Mi NaingWin KhineMaung Maung Wint2009-06-302009-06-301994-12-011994-12-01Thaw Zin, May Aye Than, Tin Tin Lay, Cho Cho, Tin Ohn, Tin Mi Mi Naing, Win Khine, Maung Maung Wint. Clinical trial to determine the antidiarrhoeal potential of traditional medicine formulations TMFs-16, TMF-35a and TMF-43. Myanmar Health Sciences Research Journal. 1994; 6(3): 127-132http://imsear.searo.who.int/handle/123456789/127024Clinical trial to determine the therapeutic efficacy of three Traditional Medicine Formulations, claimed to have antidiarrhoeal action, were studied on 150 acute diarrhoeal patients admitted to the Infectious Diseases Hospital, Yangon. TMF-16 was found to possess a good antidiarrhoeal action with the antidiarrhoeal index (ADI) of 28.71 percent, which is approximately equal to that of the standard drug, loparamide which had the ADI of 27.94 percent. TMF-35a also possess a mild to moderate antidiarrhoeal action (ADI = 21.5 percent), but TMF-43 showed little or no antidiarrhoeal action (ADI = 9.64 percent). The cllinical significance of the study is that both TMF-16 and loparamide were found to reduce the stool output as well as the amount of fluid replacement required. TMF-16 is well tolerated, available locally and cheaply, and thus, may prove beneficial in the symptomatic relief of non-specific acute diarrhoea.Clinical TrialsFormulariesAntidiarrhealsMedicine, Myanmar TraditionalMyanmar