Kharwade, Rohini SVyavhare, Neha SMore, Sachin M2015-08-052015-08-052011-01Kharwade Rohini S, Vyavhare Neha S, More Sachin M. Formulation of mucoadhesive tablet by using aegle marmelos gum. International Journal of Applied Biology and Pharmaceutical Technology. 2011 Jan-Mar; 2(1): 145-153.0976-4550http://imsear.searo.who.int/handle/123456789/161346In the present work, the mucoadhesive tablet of diclofenac (as a model drug) by using Aegle marmelos fruit gum as a binder was formulated. The preliminary evaluation of Aegle marmelos gum showed that bulk density 0.42 ± 0.2 g/cm3, tapped density 0.45 ± 0.3 g/cm3 and angle of repose 290 ± 0.15. The six tablet formulation were prepared by using 0.25%, 0.50%, 0.75%, 1%, 1.25% and 1.50% w/w of Aegle marmelos gum by direct compression (F1,F2,F3,F4 and F5 respectively). Tablets were subjected for evaluation of uniformity of weight, hardness, friability, drug content uniformity, swelling behavior, release rate study, mucoadhesive study, and tensile strength study. Formulation was studied for drug additive interaction (FTIR). F4 is found to be optimized formulation. The in-vitro drug release of F4 formulation exhibits complete release of Diclofenac Sodium with non fiction first order release kinetic. The formulation F4 exhibited tensile strength 0.27 N with 10 hrs of mucoadhesion. From the study it can be conclude that the Aegle marmelos gum used as mucoadhesive sustained release matrix tablet.enAegle marmelos gumMucoadhesive tabletsArticle