Onoja, Remigius IbeJoshua, Parker ElijahObidah, WilsonOnyekaba, Alloysius ChibuzorMgbeahurike, Anthony ChristianEmesiani, Benjamin Ifechukwu2023-08-092023-08-092023-01Onoja Remigius Ibe, Joshua Parker Elijah, Obidah Wilson, Onyekaba Alloysius Chibuzor, Mgbeahurike Anthony Christian, Emesiani Benjamin Ifechukwu. Modulatory effects of Saccharomyces cerevisiae var. boulardii on experimentally induced benign prostatic hyperplasia in rats. Indian Journal of Experimental Biology. 2023 Jan; 61(1): 25-320975-10090019-5189http://imsear.searo.who.int/handle/123456789/222591Benign prostatic hyperplasia (BPH) is an age-related non-neoplastic disease of the prostate gland in men that has become a global health issue in recent years. Due to the side effects of conventional treatment options, attention is now focused on phytotherapeutics for its management. We investigated the possible protective effect of Saccharomyces cerevisiae var. boulardii in a rat model of testosterone propionate (TP) induced BPH. Rats were divided into five groups: Gr. I, untreated control group; Gr. II, TP group; Gr. III, TP + finasteride; Gr. IV, TP + S. cerevisiae var. boulardii; and Gr. V, S. cerevisiae var. boulardii group. Treatments were given daily for 28 days. At the end of the experiment, all rats were weighed and the prostatic indices, prostate specific antigen, serum testosterone concentration as well as the histological and histomorphometric changes were evaluated. Saccharomyces cerevisiae var. boulardii significantly (P <0.05) reduced prostate weight, prostatic index, serum prostate specific antigen, prostatic epithelial thickness and increased luminal diameter. Thus, the results of this study suggest that S. cerevisiae var. boulardii is a potential pharmacological candidate for management of benign prostatic hyperplasia.DihydrotestosteroneProbioticProstate glandRodentsTestosterone propionateYeastJournal ArticleIndiaDepartment of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, NigeriaDepartment of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka, NigeriaDepartment of Biochemistry, School of Life Sciences, Modibbo Adama University of Technolog, Yola, NigeriaInstitute for Drug-Herbal Medicine-Excipient Research and Development, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria