Maharshi, VikasRehan, Harmeet SinghGupta, Lalit KumarYadav, Madhur2016-12-082016-12-082016-04Vikas Maharshi*, Harmeet Singh Rehan, Lalit Kumar Gupta and Madhur Yadav. Comparison of Effect of Enalapril and Losartan Monotherapy on Quality of Life and Safety of Stage 1 Hypertensive Patients. Indian Journal of Physiology and Pharmacology. 2016 Apr-Jun; 60(2): 174-181.0019-5499http://imsear.searo.who.int/handle/123456789/179556An open label randomized controlled study was conducted to compare the quality of life (QoL) and safety of newly diagnosed stage 1 hypertensive patients randomized into two groups of 30 receiving either enalapril 5 mg or losartan 50 mg per-oral once daily for three months. QoL was assessed at the baseline and at the end of study using SF-36v2 health care questionnaire. Adverse drug reactions (ADRs) were monitored. Investigations at baseline were compared with those after intervention. Pre & post-intervention QoL transformed scores within each group and change in the same between two groups were analyzed using paired and unpaired t-test respectively. Transformed scores of role limitation due to energy/fatigue, emotional well being and general health domains improved significantly in both treatment groups. Scores of bodily pain improved significantly (p=0.0008) in losartan group only. Results were not significantly different between two groups (except for bodily pain). No serious ADR was reported.enArticle