Verghese, RSrinath, SJayaram, C2023-07-142023-07-142022-12Verghese R, Srinath S, Jayaram C. Circulating Tumor Cells – A Review. Oral and Maxillofacial Pathology Journal. 2022 Dec; 13(2): 141-1452322-03840976-1225http://imsear.searo.who.int/handle/123456789/218482Context: Circulating tumor cells (CTCs) are those cells that separate from the primary tumor to enter circulation. This is facili- tated by Epithelial -Mesenchymal Transition (EMT) or through Non EMT based modalities by passive entry into circulation. CTCs are responsible for causing distant metastasis. Objectives: This review article briefly describes few of the mechanisms of CTC production and survival and few methods that are used to detect CTCs Materials and Methods: Data was collected and analyzed from published literature and electronic database searches of PubMed and Google Scholar. Result: CTCs acquire genetic alteration that differentiates them from the primary tumor. Majority of CTCs do not survive in the circulation but the few that do, do so by adapting various survival mechanisms. Conclusion: Detection of CTCs help in the early diagnosis of cancer, providing patient tailored therapy and for monitoring of cancer.Circulating Tumor Cellscancermetastasisepithelial-mesenchymal transitionJournal ArticleIndiaDepartment of Oral Pathology and Microbiology, Government Dental College and Research Institute, Bengaluru, India