Bhattacharjee, SankhajitJaiswal, Rishi KumarYadava, Pramod Kumar2020-11-182020-11-182019-03Bhattacharjee Sankhajit, Jaiswal Rishi Kumar, Yadava Pramod Kumar. Measles virus phosphoprotein inhibits apoptosis and enhances clonogenic and migratory properties in HeLa cells. Journal of Biosciences. 2019 Mar; 44(1): 1-90250-59910973-7138http://imsear.searo.who.int/handle/123456789/214435Measles virus is the causative agent of measles, a major cause of child mortality in developing countries. Two majorproteins, coded by the viral genome, are nucleocapsid protein (N) and phosphoprotein (P). The N protein protects the viralgenomic RNA and forms ribonucleoprotein complex (RNP) together with P protein. MeV-P protein recruits the largeprotein (L), i.e. viral RNA-depended RNA polymerase (RdRp), to ensure viral replication in host cell. Apoptogenicproperties of N protein of Edmonston vaccine strain have been established in our lab previously. We investigated the role ofMeV-P protein of Edmonston vaccine strain as modulator of apoptosis in cervical cancer cell line (HeLa) and found thatMeV-P protein is anti-apoptotic and enhances cell proliferation. Measles virus is considered to be innately oncotropic virus.However, the anti-apoptotic property of MeV-P protein raises important concerns while adopting this virus as an anti-cancertherapeutic tool.Anti-apoptosiscell migrationclonogenicity, HeLa cellsmeasles virusphosphoproteinVimentinJournal ArticleIndiaApplied Molecular Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110 067, India