Saini, IshaMukherjee, AparnaGautam, HitenderSingla, MohitJat, KRLodha, RakeshSingh, Urvashi BKabra, SK2020-04-232020-04-232018-12Saini Isha, Mukherjee Aparna, Gautam Hitender, Singla Mohit, Jat KR, Lodha Rakesh, Singh Urvashi B, Kabra SK. Diagnostic Yield of Xpert MTB/RIF in Bronchoalveolar Lavage in Children with Probable Pulmonary Tuberculosis. Indian Pediatrics. 2019 Dec; 55(12): 1062-10650974-75590019-6061http://imsear.searo.who.int/handle/123456789/199114Objective: To evaluate utility of XpertMTB/RIF in bronchoalveolar lavage fluid in childrenwith probable pulmonary tuberculosis. Methods: Children with probable pulmonarytuberculosis with negative smear and Xpert on induced sputum/gastric aspirate weresubjected to bronchoalveolar lavage (BAL) for Xpert assay and mycobacterial liquid culture.Data of children <14 y undergoing bronchoscopy for suspected MDR-TB (n=12) were alsoanalyzed. The sensitivity of Xpert in BAL fluid for diagnosis of probable and confirmedpulmonary tuberculosis was calculated with clinico-radiological diagnosis and culture as goldstandards, respectively. Results: Of 41 enrolled children, 24 (58.5%) had Xpert positive inBAL fluid and 11 (26.8%) had culture confirmed tuberculosis (BAL fluid;10; sputum,1). Thesensitivity of Xpert in BAL fluid among probable and culture confirmed tuberculosis caseswas 58.5% (24/41) and 81.8% (9/11), respectively. Conclusion: Xpert in bronchoalveolarlavage fluid has good sensitivity in both probable and confirmed pulmonary tuberculosis inchildrenGuidelinesImmunityInfectionsPreventionVaccinationJournal ArticleIndiaDepartments of Pediatrics, All India Institute of Medical Sciences, New Delhi, IndiaMicrobiology, All India Institute of Medical Sciences, New Delhi, India