Krishnamurthy, KritikaMohapatra, SudhesnaMishra, T KJha, Nikhil2016-01-152016-01-152015-07Krishnamurthy Kritika, Mohapatra Sudhesna, Mishra T K, Jha Nikhil. Early onset mixed cryoglobulinemia in hepatitis C. Indian Journal of Pathology & Microbiology. 2015 Jul-Sept 58(3): 381-383.http://imsear.searo.who.int/handle/123456789/170472Cryoglobulinemia is one of the most common forms of extrahepatic manifestation of chronic hepatitis infection. The phenomenon is generally seen after several years of chronicity predominantly in the female population resulting in arthralgias, purpuras, and other symptoms, due to vasculitis. Here we present a case of incomplete mixed cryoglobulinemia Type III (as per Brouet’s classifi cation) in a young boy aged 13 years who presented with an unusual symptom of pruritus. Diagnosis was confi rmed by cryoprecipitation test followed by immunofi xation. We aim to highlight the diffi culty in diagnosis of this rare case/presentation, important investigation pitfalls and how to avoid them.enCryoglobulinemiacryoprecipitation testhepatitis Cimmunofi xationpruritusArticle