BIOCOMPATIBILITY, CYTOTOXICITY AND PHYTOCHEMICAL ANALYSIS OF PLANTAGO LANCEOLATA L. AERIAL EXTRACTS: IN VITRO AND IN VIVO STUDY

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dc.contributor.authorRahamouz-Haghighi, Samanehen_US
dc.contributor.authorSharafi, Alien_US
dc.date.accessioned2025-05-09T06:14:11Z
dc.date.available2025-05-09T06:14:11Z
dc.date.issued2024-07
dc.description.abstractPlantago lanceolata L. is classified as Plantaginaceae family. Its bioactive properties have been documented in scientific literature, suggesting its efficacy in therapeutic interventions across a spectrum of medical conditions, with a particular focus on cancer treatment. The acetonic and alcoholic extracts of P. lanceolata aerial organs were subjected to the MTT technique, Artemia salina, oral acute hemolysis, GC-MS, and phytochemical screening to determine their in vitro cytotoxic impact, in vivo toxicity, biocompatibility, and phytochemical screening, respectively. The P. lanceolata acetonic extracts exhibited the lowest IC values on HCT-116 and HEK-50 293 cells. Between 185.04 and 123.98 ?g/mL. P. lanceolata extracts in methanol and ethanol showed no toxicity against A. salina (LC : 27.25 mg/mL and 14.42 mg/mL). For four hours, the tested dosages of the alcoholic extract on50 red blood cells showed no signs of toxicity. One week following treatment, ethanolic and methanolic extracts of P. lanceolata were not deadly when taken orally. On the Hodge and Sterner scale, P. lanceolata extracts showed no indications of toxicity. P. lanceolata's methanolic extract was described by its primary chemical elements, including n-hexadecanoic acid (15.00%); octadecanoic acid (9.80%); cis-vaccenic acid (5.66%), and 2,3-dihydroxysuccinic acid (5.66%). P. lanceolata acetonic extract contained n-hexadecanoic acid(1.53%), oleic Acid (1.34%) and linoleic acid (1.15%). The methanolic and ethanolic extracts did not induce hemolysis and were more cytotoxic against HCT- 116 compared to HEK-293. From a pharmaceutical point of view, if toxic drugs show selective toxicity against cancer cells and are non-toxic against normal cells, it is considered advantageous.en_US
dc.identifier.affiliationsDepartment of Plant Production and Genetics, Faculty of Agriculture, University of Zanjan, Zanjan, Iranen_US
dc.identifier.affiliationsDepartment of Plant Production and Genetics, Faculty of Agriculture, University of Zanjan, Zanjan, Iranen_US
dc.identifier.citationRahamouz-Haghighi Samaneh, Sharafi Ali . BIOCOMPATIBILITY, CYTOTOXICITY AND PHYTOCHEMICAL ANALYSIS OF PLANTAGO LANCEOLATA L. AERIAL EXTRACTS: IN VITRO AND IN VIVO STUDY. Era's Journal of Medical Research. 2024 Jul; 11(1): 8-24en_US
dc.identifier.issn2348-9839
dc.identifier.issn2394-5222
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/242628
dc.languageenen_US
dc.publisherEra's Lucknow Medical College & Hospital, Lucknow in association with American University of Barbados (AUB)en_US
dc.relation.issuenumber1en_US
dc.relation.volume11en_US
dc.source.urihttps://doi.org/10.24041/ejmr2024.2en_US
dc.subjectAcute Oral Toxicityen_US
dc.subjectBrine Shrimp Larvaeen_US
dc.subjectColorectal Cancer Cellen_US
dc.subjectHemolysisen_US
dc.subjectHuman Embryonic Kidney Cellen_US
dc.subjectGC-MS.en_US
dc.titleBIOCOMPATIBILITY, CYTOTOXICITY AND PHYTOCHEMICAL ANALYSIS OF PLANTAGO LANCEOLATA L. AERIAL EXTRACTS: IN VITRO AND IN VIVO STUDYen_US
dc.typeJournal Articleen_US
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