Acute haemodynamic effects of nicorandil in patients with chronic severe regurgitant valvular lesions.

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dc.contributor.authorYadav, Ren_US
dc.contributor.authorBhargava, Ben_US
dc.contributor.authorAggarwal, Ren_US
dc.contributor.authorNarang, Ren_US
dc.contributor.authorChopra, Aen_US
dc.contributor.authorSapra, Ren_US
dc.contributor.authorManchanda, S Cen_US
dc.date.accessioned1998-03-12en_US
dc.date.accessioned2009-05-27T04:24:01Z
dc.date.available1998-03-12en_US
dc.date.available2009-05-27T04:24:01Z
dc.date.issued1998-03-12en_US
dc.description.abstractThe haemodynamic effects of nicorandil, a new balanced vasodilator exhibiting nitrate-like as well as potassium-channel opening activity in patients with chronic severe valvular lesions have not been reported. We studied the acute effect of nicorandil on haemodynamics in 12 stable patients (6 males, 6 females; mean age 23.5 +/- 4.6 years) with chronic severe valvular regurgitation (8 mitral, 4 aortic). All patients were studied in resting, supine and fasting states. All cardioactive drugs were withdrawn five days prior to the study. Intra-arterial line was placed and thermodilution catheter was positioned in the pulmonary artery. Haemodynamic parameters recorded at baseline and at 30, 60, 90 and 120 minutes following a single oral dose of 20 mg nicorandil revealed no significant change in the heart rate while systemic pressures showed a small decline (p < 0.05). There was significant reduction in systolic, diastolic and mean pulmonary artery pressures (p < 0.001). The mean cardiac index increased from 3.16 L/min/m2 at baseline to 3.77 L/min/m2 at 60 minutes. Both the pulmonary and systemic vascular resistance indices reduced significantly, the peak fall being 18 percent and 29 percent, respectively. Maximal changes were observed at 60 to 90 minutes following administration of nicorandil. No adverse effect of nicorandil occurred during the study. We conclude that nicorandil has a favourable acute haemodynamic effect in patients with chronic severe valve regurgitation. Its long-term use in valvular lesions should be explored further.en_US
dc.description.affiliationDepartment of Cardiology, All India Institute of Medical Sciences, New Delhi.en_US
dc.identifier.citationYadav R, Bhargava B, Aggarwal R, Narang R, Chopra A, Sapra R, Manchanda SC. Acute haemodynamic effects of nicorandil in patients with chronic severe regurgitant valvular lesions. Indian Heart Journal. 1998 Mar-Apr; 50(2): 173-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/4662
dc.language.isoengen_US
dc.source.urihttps://indianheartjournal.comen_US
dc.subject.meshAdministration, Oralen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAortic Valve Insufficiency --drug therapyen_US
dc.subject.meshChronic Diseaseen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHemodynamics --drug effectsen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMitral Valve Insufficiency --drug therapyen_US
dc.subject.meshNiacinamide --administration & dosageen_US
dc.subject.meshNicorandilen_US
dc.subject.meshPotassium Channels --agonistsen_US
dc.subject.meshRheumatic Heart Disease --complicationsen_US
dc.subject.meshTreatment Outcomeen_US
dc.subject.meshVasodilator Agents --administration & dosageen_US
dc.subject.meshVentricular Dysfunction, Left --prevention & controlen_US
dc.titleAcute haemodynamic effects of nicorandil in patients with chronic severe regurgitant valvular lesions.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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