Association between PITX2 polymorphism and androgenetic alopecia in the Indian population

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dc.contributor.authorMurugan, Men_US
dc.contributor.authorSadasivam, IPen_US
dc.contributor.authorManoharan, Aen_US
dc.contributor.authorJayakumar, Sen_US
dc.contributor.authorVetriselvan, Yen_US
dc.contributor.authorSamuel, MSen_US
dc.contributor.authorSambandam, R.en_US
dc.date.accessioned2025-06-18T11:42:21Z
dc.date.available2025-06-18T11:42:21Z
dc.date.issued2025-04
dc.description.abstractBackground: Androgenetic alopecia, also known as male pattern baldness, is a common form of hair loss influenced by environmental, hormonal, and genetic factors. According to recent research, the PITX2 gene may play a key role in the pathophysiology of androgenetic alopecia (AGA). Objectives: This study examines the association between genetic variants of the PITX2 gene and AGA risk. Methods: The genomic DNA was extracted from peripheral blood samples collected from 70 male AGA patients and 60 non-androgenetic alopecia controls. The isolated DNA was quantified and the genotype for three PITX2 polymorphisms (rs2200733, rs10033464, and rs13143308) was identified using TaqMan assays. The statistical analysis was done to determine the allele frequency of genetic variants between AGA and non-AGA groups. Results: The demographic profile of the study population showed that the AGA and non-AGA groups differed in age. The AGA group had higher blood pressure, a higher prevalence of smoking, alcohol consumption, metabolic syndrome, insulin resistance, and a higher incidence of family history. Through genetic analysis, significant correlations were found between AGA risk and specific PITX2 polymorphisms, significantly with the rs2200733 allele (OR = 6.08, p < 0.001*), the rs1003464 G allele (OR = 2.02, p < 0.019*) and the rs13143308 showed GT genotype (OR = 4.26, p < 0.001*). Conclusion: Based on our findings, the PITX2 polymorphisms may play a vital role in the development of AGA. This study also found the interactions between genetic and environmental factors in AGA pathogenesis.en_US
dc.identifier.affiliationsDepartment of Medical Biotechnology, Aarupadai Veedu Medical College & Hospital, Vinayaka Mission’s Research Foundation (Deemed to be University), Kirumampakkam, Puducherry, Indiaen_US
dc.identifier.affiliationsDepartment of Dermatology, Venereology and Leprosy, Aarupadai Veedu Medical College & Hospital, Vinayaka Mission’s Research Foundation (Deemed to be University), Kirumampakkam, Puducherry, Indiaen_US
dc.identifier.affiliationsDepartment of Medical Biotechnology, Aarupadai Veedu Medical College & Hospital, Vinayaka Mission’s Research Foundation (Deemed to be University), Kirumampakkam, Puducherry, Indiaen_US
dc.identifier.affiliationsDepartment of Medical Biotechnology, Aarupadai Veedu Medical College & Hospital, Vinayaka Mission’s Research Foundation (Deemed to be University), Kirumampakkam, Puducherry, Indiaen_US
dc.identifier.affiliationsDepartment of Medical Biotechnology, Aarupadai Veedu Medical College & Hospital, Vinayaka Mission’s Research Foundation (Deemed to be University), Kirumampakkam, Puducherry, Indiaen_US
dc.identifier.affiliationsSaveetha Medical College and Hospital, Thandalam, Chennai, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsDepartment of Medical Biotechnology, Aarupadai Veedu Medical College & Hospital, Vinayaka Mission’s Research Foundation (Deemed to be University), Kirumampakkam, Puducherry, Indiaen_US
dc.identifier.citationMurugan M, Sadasivam IP, Manoharan A, Jayakumar S, Vetriselvan Y, Samuel MS, Sambandam R.. Association between PITX2 polymorphism and androgenetic alopecia in the Indian population. Indian Journal of Dermatology, Venereology and Leprology. 2025 Apr; 91(2): 158-162en_US
dc.identifier.issn0378-6323
dc.identifier.issn0973-3922
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/249387
dc.languageenen_US
dc.publisherScientific Scholar on behalf of Indian Association of Dermatologists, Venereologists & Leprologists (IADVL), India.en_US
dc.relation.issuenumber2en_US
dc.relation.volume91en_US
dc.source.urihttps://dx.doi.org/10.25259/IJDVL_1147_2023en_US
dc.subjectPITX2en_US
dc.subjectAndrogenetic alopeciaen_US
dc.subjectSingle nucleotide polymorphismen_US
dc.subjectGenetic variationen_US
dc.titleAssociation between PITX2 polymorphism and androgenetic alopecia in the Indian populationen_US
dc.typeJournal Articleen_US
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