Mitochondrial Dysfunction, Oxidative Stress and Premature Aging in Children With Nutritional Rickets
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Date
2024-08
Journal Title
Journal ISSN
Volume Title
Publisher
The Indian Academy of Pediatrics
Abstract
Objective: To assess the mitochondrial dysfunction, oxidative stress and premature aging in children with nutritional rickets. Methods: This cross-sectional study enrolled children aged 6 months - 5 years with nutritional rickets attending a tertiary care hospital between January 2021 and August 2022. Mitochondrial dysfunction, oxidative stress and premature aging were assessed by measuring the mitochondrial DNA (mtDNA) content, total antioxidant status (TAOS) and telomere length (TL) in 40 children with nutritional rickets and 40 age- and sex- matched healthy children without rickets (controls). Results: The median (IQR) mtDNA content was significantly higher in children with rickets as compared to controls [152.27 (111.83, 218.66) vs 93.7 (72.5, 134.14); P < 0.001], implying mitochondrial dysfunction attributed to increased mitochondrial biogenesis in children with rickets. The median (IQR) TAOS ( mM Trolox equiv.) was significantly lower in children with rickets than controls [4.54 (3.93, 5.73) vs 7.86 (5.09, 9.58); P < 0.001)]. The median (IQR) TL in cases was significantly longer in children with rickets compared to controls [417.31 (111.83,218.66) vs 93.7 (72.5,134.14); P < 0.001] implying that children with rickets do not have premature aging. Conclusion: Children with rickets have high oxidative stress and mitochondrial dysfunction but no evidence of premature aging.
Description
Keywords
Antioxidant, Cell death, Mitochondrial DNA, Telomere length, Vitamin D deficiency
Citation
Lakshmi Raaj, Aaradhana, Mehndiratta Mohit, Shah Dheeraj, Gupta Piyush . Mitochondrial Dysfunction, Oxidative Stress and Premature Aging in Children With Nutritional Rickets. Indian Pediatrics. 2024 Aug; 61(8): 750-755