Analytical approach to estimate normal tissue complication probability using best fit of normal tissue tolerance doses into the NTCP equation of the linear quadratic model.

Simple item page
dc.contributor.authorKehwar, T Sen_US
dc.date.accessioned2005-07-14en_US
dc.date.accessioned2009-06-01T16:25:51Z
dc.date.available2005-07-14en_US
dc.date.available2009-06-01T16:25:51Z
dc.date.issued2005-07-14en_US
dc.description.abstractAIMS AND OBJECTIVES: Aims and objectives of this study are to get the best fit of the normal tissue tolerance doses to the NTCP model of the linear quadratic model. METHODS AND MATERIALS: To compute the NTCP, the modified form of the Poisson cell kill model of NTCP, based on linear-quadratic model, is used. The model has been applied to compute the parameters of the NTCP model using clinical tolerance doses of various normal tissues / organs extracted from published reports of various authors. The normal tissue tolerance doses are calculated for partial volumes of the organs using the values of above-said parameters for published data on normal tissue tolerance doses. In this article, a graphical representation of the computed NTCP for bladder, brain, heart and rectum is presented. RESULTS AND CONCLUSION: A fairly good correspondence is found between the curves of 2 sets of data for brain, heart and rectum. Hence the model may, therefore, be used to interpolate clinical data to provide an estimate of NTCP for these organs for any altered fractionated treatment schedule.en_US
dc.description.affiliationDepartment of Radiotherapy, Postgraduate Institute of Medical Education and Research, Chandigarh - 160 012, India. drkehwar@yahoo.comen_US
dc.identifier.citationKehwar TS. Analytical approach to estimate normal tissue complication probability using best fit of normal tissue tolerance doses into the NTCP equation of the linear quadratic model. Journal of Cancer Research and Therapeutics. 2005 Jul-Sep; 1(3): 168-79en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/111546
dc.language.isoengen_US
dc.source.urihttps://www.cancerjournal.neten_US
dc.subject.meshHumansen_US
dc.subject.meshModels, Biologicalen_US
dc.subject.meshNeoplasms --radiotherapyen_US
dc.subject.meshProbabilityen_US
dc.subject.meshRadiation Toleranceen_US
dc.subject.meshRadiotherapy --adverse effectsen_US
dc.titleAnalytical approach to estimate normal tissue complication probability using best fit of normal tissue tolerance doses into the NTCP equation of the linear quadratic model.en_US
dc.typeJournal Articleen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Journal of Cancer Research and Therapeutics