Neurotoxic Effects of Aspirin on the Developing Mouse Cerebellum: Implications for Human Health
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Date
2023-06
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International Research Organization for Life & Health Sciences
Abstract
Introduction: Aspirin is a non-steroidal anti-inflammatory drug (NSAID). Pregnant women often seek relief from commondiscomforts such as headaches, fever, and arthritis by easily purchasing it over-the-counter. NSAIDs are commonly usedduring pregnancy, especially for managing chronic conditions such as inflammatory bowel disease, rheumatoid arthritis,and spondyloarthropathy. In addition, aspirin may be prescribed for obstetrical complications such as preterm labor andpolyhydramnios. However, before prescribing long-term aspirin therapy, health-care professionals carefully evaluate the benefitsagainst the potential complications associated with its use. Despite the extensive use of aspirin during pregnancy, there islimited literature available on its potentially harmful effects on fetal development. Therefore, the present study aims to addressthis knowledge gap by investigating the teratogenicity of aspirin.Materials and Methods: Pregnant Swiss albino mice were divided into two groups of 151 mice each: control and treated.Aspirin was given to the treated group at a dose of 100 mg/kg body weight from the 3rd to the 5th day of gestation. The controlgroup received an equivalent amount of tap water. The mouse from each group was sacrificed on the 19th day of gestation.After fixation in a 10% neutral formalin solution, the brains of the fetuses were dissected, photographed, and further processedfor histological observations.Results: On histological observation of the brain, the cerebellum of the treated fetuses showed many pathological changes.Conclusion: Aspirin, although widely used, may cause toxicity and teratogenicity. Clinicians, therefore, need to be cautiousand judicious when prescribing aspirin to pregnant women, being aware of its potential embryo-fetal toxicity
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Keywords
Cerebellum, Neurotoxicity, Teratogenicity
Citation
Yadav S. Neurotoxic Effects of Aspirin on the Developing Mouse Cerebellum: Implications for Human Health. International Journal of Scientific Study. 2023 Jun; 11(3): 80-83