Antioxidant and Radical Scavenging Properties of β-Carotene on Cisplatin Induced Cardiotoxicity.

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dc.contributor.authorKiran, B Uday
dc.contributor.authorSushma, M
dc.contributor.authorPrasad, K V S R G
dc.contributor.authorRao, V Uma Maheshwara
dc.contributor.authorBai, D Jhansi Laxmi
dc.contributor.authorNisheetha, V
dc.date.accessioned2017-01-04T05:38:26Z
dc.date.available2017-01-04T05:38:26Z
dc.date.issued2015
dc.description.abstractObjective: To investigate the protective role of β-Carotene against cisplatin induced cardiotoxicity in male albino rats. Methods: Various biochemical parameters such as Creatine kinase-MB, Lactate dehydrogenase (LDH), Alkaline phosphatase (ALP), Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Triglycerides (TG) and Total cholesterol (TC) are being assessed. Also the levels of the in vivo antioxidants such as Reduced glutathione (GSH), Catalase (CAT), and Malondialdehyde (MDA) in the post mitochondrial supernatant of heart were measured. In addition, the histopathological studies were performed to study the protective activity of β-carotene. Results: Cisplatin administration has shown the elevated levels of the cardiac markers and diminished the endogenous antioxidant levels when compared with the normal rats. β-carotene treatment showed the inhibitory effect on the free radicals showing decreased levels of the cardiac markers like CK-MB, LDH, AST, ALT and ALP. The β-carotene treated rats showed significant (p<0.001) decrease in lipid peroxidation in both prophylactic and curative groups when compared to the cisplatin group. Also showed a significant (p<0.05, p<0.001) increase in the levels of GSH in prophylactic and curative group respectively when compared with the cisplatin group. Both prophylactic and curative groups have shown a significant (p<0.001) increase in the levels of CAT. Further, the histopathological studies confirm the protective effect of β-carotene. Conclusion: These findings justify the biological and traditional uses of β-carotene as confirmed by its promising radical scavenging activity against cisplatin induced cardiotoxicity.en_US
dc.identifier.citationKiran B Uday, Sushma M, Prasad K V S R G, Rao V Uma Maheshwara, Bai D Jhansi Laxmi, Nisheetha V. Antioxidant and Radical Scavenging Properties of β-Carotene on Cisplatin Induced Cardiotoxicity. Cardiology and Angiology An International Journal. 2015; 4(3): 98-106.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/181063
dc.language.isoenen_US
dc.source.urihttps://www.sciencedomain.org/abstract/10292en_US
dc.subjectβ-Caroteneen_US
dc.subjectcardiotoxicityen_US
dc.subjectlipid peroxidationen_US
dc.subjectreduced glutathioneen_US
dc.subjectcatalaseen_US
dc.subjectpost mitochondrial supernatanten_US
dc.titleAntioxidant and Radical Scavenging Properties of β-Carotene on Cisplatin Induced Cardiotoxicity.en_US
dc.typeArticleen_US
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