Antioxidant and Radical Scavenging Properties of β-Carotene on Cisplatin Induced Cardiotoxicity.
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Date
2015
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Abstract
Objective: To investigate the protective role of β-Carotene against cisplatin induced cardiotoxicity in
male albino rats.
Methods: Various biochemical parameters such as Creatine kinase-MB, Lactate dehydrogenase
(LDH), Alkaline phosphatase (ALP), Aspartate aminotransferase (AST), Alanine aminotransferase
(ALT), Triglycerides (TG) and Total cholesterol (TC) are being assessed. Also the levels of the in
vivo antioxidants such as Reduced glutathione (GSH), Catalase (CAT), and Malondialdehyde (MDA)
in the post mitochondrial supernatant of heart were measured. In addition, the histopathological
studies were performed to study the protective activity of β-carotene.
Results: Cisplatin administration has shown the elevated levels of the cardiac markers and
diminished the endogenous antioxidant levels when compared with the normal rats. β-carotene
treatment showed the inhibitory effect on the free radicals showing decreased levels of the cardiac markers like CK-MB, LDH, AST, ALT and ALP. The β-carotene treated rats showed significant
(p<0.001) decrease in lipid peroxidation in both prophylactic and curative groups when compared to
the cisplatin group. Also showed a significant (p<0.05, p<0.001) increase in the levels of GSH in
prophylactic and curative group respectively when compared with the cisplatin group. Both
prophylactic and curative groups have shown a significant (p<0.001) increase in the levels of CAT.
Further, the histopathological studies confirm the protective effect of β-carotene.
Conclusion: These findings justify the biological and traditional uses of β-carotene as confirmed by
its promising radical scavenging activity against cisplatin induced cardiotoxicity.
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Keywords
β-Carotene, cardiotoxicity, lipid peroxidation, reduced glutathione, catalase, post mitochondrial supernatant
Citation
Kiran B Uday, Sushma M, Prasad K V S R G, Rao V Uma Maheshwara, Bai D Jhansi Laxmi, Nisheetha V. Antioxidant and Radical Scavenging Properties of β-Carotene on Cisplatin Induced Cardiotoxicity. Cardiology and Angiology An International Journal. 2015; 4(3): 98-106.