Change in Carbapenem Susceptibility Patterns among Urinary Escherichia coli isolates at a Tertiary Care Centre

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dc.contributor.authorTevatia, Manvir Singhen_US
dc.contributor.authorKalra, Dinesh Kumaren_US
dc.contributor.authorMukherjee, Tanushrien_US
dc.contributor.authorSengupta, Prashanten_US
dc.date.accessioned2020-09-24T07:11:27Z
dc.date.available2020-09-24T07:11:27Z
dc.date.issued2019-12
dc.description.abstractIntroduction: Escherichia coli (E.coli) is the major pathogencausing urinary tract infections (UTIs), and carbapenems areprescribed frequently to treat UTIs at tertiary care settings. Itis, therefore, of clinical importance to determine the changein carbapenem susceptibility of E.coli isolated from urinarysamples after adopting a new cleaning policy. Study aimed todetermine the change in antimicrobial susceptibility of E.colistrains isolated from urinary samples towards carbapenems.Material and methods: A retrospective comparison ofcarbapenems susceptibility profile of E.coli isolated fromurine cultures at a tertiary care centre was carried out for twoyears between 2017 and 2018. E.coli isolates were identifiedfrom positive cultures as per the conventional microbiologicalmethods. Carbapenem susceptibility was exhibited usingMeropenem (10 µg) disk on Mueller-Hinton Agar (MHA)using Kirby Bauer disk diffusion method.Results: In a total of 1219 urinary E.coli isolates, sensitivitytowards carbapenems has increased from 81.3% to 84.2%(overall 83.2%). The value of chi-square for the differencein the distribution of Meropenem susceptibility for 2017 and2018 was found to be <0.001, which is highly significant.Hence, the susceptibility profile of Meropenem changedsignificantly in two consecutive years in this tertiary carehospital after adopting a new cleaning policy.Conclusion: E.coli is the leading pathogen causing UTIs,and carbapenems are prescribed frequently, so regularmonitoring of antimicrobial susceptibility is recommended.Better cleaning policies can improve the sensitivity patternsof isolates towards antimicrobials.en_US
dc.identifier.affiliationsConsultant (Pathology) & Trained in GI Pathology & HOD, Department of Pathology, Command Hospital (Southern Command), Pune, Maharashtraen_US
dc.identifier.affiliationsGraded Specialist (Microbiology), Department of Pathology, Command Hospital (Southern Command), Pune, Maharashtraen_US
dc.identifier.affiliationsCommanding Officer & Sr Adv in Pathology, 318 Field Hospital, C/o 56 APOen_US
dc.identifier.affiliationsClassified Specialist (Pathology) & Trained in Nephropathology, Department of Pathology, Command Hospital (Southern Command), Pune, Maharashtra, Indiaen_US
dc.identifier.citationTevatia Manvir Singh, Kalra Dinesh Kumar, Mukherjee Tanushri, Sengupta Prashant. Change in Carbapenem Susceptibility Patterns among Urinary Escherichia coli isolates at a Tertiary Care Centre. International Journal of Contemporary Medical Research . 2019 Dec; 6(12): l5-l8en_US
dc.identifier.issn2393-915X
dc.identifier.issn2454-7379
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/202738
dc.languageenen_US
dc.publisherInternational Society for Contemporary Medical Researchen_US
dc.relation.issuenumber12en_US
dc.relation.volume6en_US
dc.source.urihttps://dx.doi.org/10.21276/ijcmr.2019.6.12.43en_US
dc.subjectE.colien_US
dc.subjectCarbapenemen_US
dc.subjectABSTen_US
dc.subjectUrine.en_US
dc.titleChange in Carbapenem Susceptibility Patterns among Urinary Escherichia coli isolates at a Tertiary Care Centreen_US
dc.typeJournal Articleen_US
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