Plasma and Erythrocyte Membrane Plasmalogens in Patients with Coronary Heart Diseases Undergoing Percutaneous Intervention

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dc.contributor.authorArita, Takeshien_US
dc.contributor.authorYokoyama, Takuen_US
dc.contributor.authorMoriyama, Shoheien_US
dc.contributor.authorIrie, Keien_US
dc.contributor.authorFukata, Mitsuhiroen_US
dc.contributor.authorOdashiro, Keitaen_US
dc.contributor.authorMaruyama, Toruen_US
dc.contributor.authorHazeyama, Seiraen_US
dc.contributor.authorMawatari, Shiroen_US
dc.contributor.authorFujino, Takehikoen_US
dc.contributor.authorAkashi, Koichien_US
dc.date.accessioned2019-12-06T09:42:10Z
dc.date.available2019-12-06T09:42:10Z
dc.date.issued2018-10
dc.description.abstractAims: Plasmalogens are unique phospholipid of biological membrane and is considered to play a potent role of intrinsic antioxidant. Atherosclerosis is associated with oxidative stress, but the correlation between plasmalogens and atherosclerosis is debatable. Therefore, this study aimed to assess the plasma and erythrocyte membrane phospholipids profile in patients with coronary heart diseases (CHD) undergoing percutaneous coronary intervention (PCI). Place and Duration of the Study: Vascular laboratory of Heart Center, Kyushu University Hospital, Fukuoka, Japan, from February to August 2016. Methodology: The plasma concentrations and erythrocyte membrane contents of phospholipids were quantified in patients with CHD (n = 30, group A) and age-matched controls (n = 38, group B) using high-performance liquid chromatography with evaporative light scattering detection method. Results: Plasma concentrations of plasmalogens in group A were significantly lower than those in group B. Similar findings were obtained from relative contents of plasmalogens in the erythrocyte membrane. Multiple regression models for plasmalogens yielded phospholipids other than plasmalogen as determinants of plasmalogens. Conclusions: This cross-sectional study indicated that plasma and erythrocyte membrane plasmalogens are reduced in patients with CHD undergoing PCI. Further longitudinal studies are required to elucidate the clinical role of intrinsic plasmalogens as a laboratory marker of oxidative stress and extrinsic plasmalogens as a novel therapy for atherosclerosis.en_US
dc.identifier.affiliationsDepartment of Medicine, Kyushu University, Fukuoka 812-8582, Japanen_US
dc.identifier.affiliationsDepartment of Medicine, Kyushu University, Fukuoka 812-8582, Japanen_US
dc.identifier.affiliationsDepartment of Medicine, Kyushu University, Fukuoka 812-8582, Japanen_US
dc.identifier.affiliationsDepartment of Medicine, Kyushu University, Fukuoka 812-8582, Japanen_US
dc.identifier.affiliationsDepartment of Medicine, Kyushu University, Fukuoka 812-8582, Japanen_US
dc.identifier.affiliationsDepartment of Medicine, Kyushu University, Fukuoka 812-8582, Japanen_US
dc.identifier.affiliationsDepartment of Medicine, Kyushu University, Fukuoka 812-8582, Japanen_US
dc.identifier.affiliationsInstitute of Rheological Function of Foods Co., Ltd., Hisayama 811-2501, Japanen_US
dc.identifier.affiliationsInstitute of Rheological Function of Foods Co., Ltd., Hisayama 811-2501, Japanen_US
dc.identifier.affiliationsBOOCS Clinic, Fukuoka 812-0025, Japanen_US
dc.identifier.affiliationsDepartment of Medicine, Kyushu University, Fukuoka 812-8582, Japanen_US
dc.identifier.citationArita Takeshi, Yokoyama Taku, Moriyama Shohei, Irie Kei, Fukata Mitsuhiro, Odashiro Keita, Maruyama Toru, Hazeyama Seira, Mawatari Shiro, Fujino Takehiko, Akashi Koichi. Plasma and Erythrocyte Membrane Plasmalogens in Patients with Coronary Heart Diseases Undergoing Percutaneous Intervention. Cardiology and Angiology: An International Journal. 2018 Oct; 7(4): 1-11en_US
dc.identifier.issn2347-520X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/188669
dc.languageenen_US
dc.publisherScience Domain Internationalen_US
dc.relation.issuenumber4en_US
dc.relation.volume7en_US
dc.source.urihttps://doi.org/10.9734/CA/2018/44602en_US
dc.subjectCoronary heart diseaseen_US
dc.subjectpercutaneous coronary interventionen_US
dc.subjecterythrocyte membraneen_US
dc.subjectplasmalogensen_US
dc.titlePlasma and Erythrocyte Membrane Plasmalogens in Patients with Coronary Heart Diseases Undergoing Percutaneous Interventionen_US
dc.typeJournal Articleen_US
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