Antisickling effects of hydroethanolic extract of Oxytenanthera abyssinica leaves

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dc.contributor.authorMbaye, Sen_US
dc.contributor.authorIbrahima, Den_US
dc.contributor.authorAwa, Ben_US
dc.contributor.authorFatoumata, Ben_US
dc.contributor.authorKhadim, FCen_US
dc.contributor.authorAbsatou, Den_US
dc.contributor.authorOumy, KMen_US
dc.contributor.authorMamadou, S.en_US
dc.date.accessioned2025-08-13T11:55:00Z
dc.date.available2025-08-13T11:55:00Z
dc.date.issued2025-06
dc.description.abstractBackground: Sickle cell disease is a hereditary hemoglobinopathy. It is characterized by the presence of abnormal hemoglobin S levels at high concentrations in red blood cells. Aim: This study aimed to investigate the potential of a hydroethanolic extract from Oxytenanthera abyssinica (AO) leaves to inhibit red blood cell sickling in individuals with sickle cell trait (HbAS) and sickle cell disease (HbSS). Methods: Ten grams of powdered AO leaves were macerated in 100 ml of a 60% hydroethanolic solution. Following filtration, the macerate was concentrated using a rotary evaporator until a dry crude extract was obtained. The dry extract was reconstituted in water to prepare three test solutions at concentrations of 2.5 and 1.25 mg/ml. Emmel tests were performed by incubating these extract solutions with blood samples obtained from individuals with sickle cell trait (HbAS), sickle cell disease (HbSS), and healthy controls (HbAA). The percentage of sickled red blood cells was determined using optical microscopy. Results: The hydroethanolic extract of AO leaves significantly reduced the percentage of sickled red blood cells in individuals with sickle cell trait (HbAS) and sickle cell disease (HbSS). The antisickling effect exhibited a dose- dependent relationship. Conclusion: Our findings indicate that the crude hydroethanolic extract of AO leaves has significant antisickling activity. This suggests a potential source of bioactive molecules for the development of low-cost therapeutic interventions against sickle cell disease.en_US
dc.identifier.affiliationsLaboratory of Pharmaceutical Physiology, Faculty of Medicine, Pharmacy, and Dentistry, Cheikh Anta Diop University, Dakar, Senegalen_US
dc.identifier.affiliationsUnit of Training and Research in Health Sciences, Assane Seck University, Ziguinchor, Senegalen_US
dc.identifier.affiliationsLaboratory of Physiologic of Medicine Department, Unit of Training and Research in Health and Sustainable Development, Alioune Diop University, Bambey, Senegalen_US
dc.identifier.affiliationsUnit of Training and Research in Health, Gaston Berger University, Saint-Louis, Senegalen_US
dc.identifier.affiliationsLaboratory of Pharmaceutical Physiology, Faculty of Medicine, Pharmacy, and Dentistry, Cheikh Anta Diop University, Dakar, Senegalen_US
dc.identifier.affiliationsLaboratory of Pharmaceutical Physiology, Faculty of Medicine, Pharmacy, and Dentistry, Cheikh Anta Diop University, Dakar, Senegalen_US
dc.identifier.affiliationsLaboratory of Pharmaceutical Physiology, Faculty of Medicine, Pharmacy, and Dentistry, Cheikh Anta Diop University, Dakar, Senegalen_US
dc.identifier.affiliationsLaboratory of Pharmaceutical Physiology, Faculty of Medicine, Pharmacy, and Dentistry, Cheikh Anta Diop University, Dakar, Senegalen_US
dc.identifier.citationMbaye S, Ibrahima D, Awa B, Fatoumata B, Khadim FC, Absatou D, Oumy KM, Mamadou S.. Antisickling effects of hydroethanolic extract of Oxytenanthera abyssinica leaves . National Journal of Physiology, Pharmacy and Pharmacology. 2025 Jun; 15(6): 314-318en_US
dc.identifier.issn2231-3206
dc.identifier.issn2320-4672
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/254523
dc.languageenen_US
dc.publisher?Eldaghayes Publisheren_US
dc.relation.issuenumber6en_US
dc.relation.volume15en_US
dc.source.urihttps://dx.doi.org/10.5455/NJPPP.2025.v15.i6.3en_US
dc.subjectSickle cell diseaseen_US
dc.subjectAntisicklingen_US
dc.subjectOxytenanthera abyssinica.en_US
dc.titleAntisickling effects of hydroethanolic extract of Oxytenanthera abyssinica leavesen_US
dc.typeJournal Articleen_US
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