Antibacterial activity of silver nanoparticles dispersion against MSSA and MRSA isolated from wounds in a tertiary care hospital of north India.

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dc.contributor.authorAnsari, Mohammad Azam
dc.contributor.authorKhan, Haris M
dc.contributor.authorKhan, Aijaz A
dc.contributor.authorSultan, Asfia
dc.contributor.authorAzam, Ameer
dc.contributor.authorShahid, Mohammad
dc.contributor.authorShujatullah, Fatima
dc.date.accessioned2015-08-22T10:11:40Z
dc.date.available2015-08-22T10:11:40Z
dc.date.issued2011-10
dc.description.abstractStaphylococcus aureus, the main cause of nosocomial infection worldwide result in significant increases in mortality, morbidity, and cost related to prolong treatments. Silver compound has been in use since time immemorial for the treatment of burns, wounds and several other bacterial infections. In the present work, we explore the antibacterial activity of silver nanoparticles (Ag-NPs) dispersion (5-10 nm) against reference strain and clinical isolates of Methicillin-sensitive S. aureus (MSSA), and Methicillin-Resistant S. aureus (MRSA).The typical minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) against standard reference strain as well as, MSSA and MRSA were observed in the range of 12-48 μg/ml and 12-96 μg/ml, respectively. The MBC/MIC ratios against all strains were found in the range of ≤1 to ≤4, which shows that Ag-NPs inhibit bacterial growth in a bactericidal rather than a bacteriostatic manner. Our finding suggests that Ag-NPs are effective broad-spectrum antibacterial agents regardless of their drug-resistance mechanisms.en_US
dc.identifier.citationAnsari Mohammad Azam, Khan Haris M, Khan Aijaz A, Sultan Asfia, Azam Ameer, Shahid Mohammad, Shujatullah Fatima. Antibacterial activity of silver nanoparticles dispersion against MSSA and MRSA isolated from wounds in a tertiary care hospital of north India. International Journal of Applied Biology and Pharmaceutical Technology. 2011 Oct-Dec; 2(4): 34-42.en_US
dc.identifier.issn0976-4550
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/162343
dc.language.isoenen_US
dc.source.urihttps://www.ijabpt.com/Details.aspx?fid=431en_US
dc.subjectMICen_US
dc.subjectMBCen_US
dc.subjectSilver nanoparticlesen_US
dc.subjectMSSAen_US
dc.subjectMRSAen_US
dc.titleAntibacterial activity of silver nanoparticles dispersion against MSSA and MRSA isolated from wounds in a tertiary care hospital of north India.en_US
dc.typeArticleen_US
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