Evaluation of Prescription Pattern of Antihypertensives and Its Compliance with Joint National Committee 8 Guidelines in Hospital Setting

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dc.contributor.authorDamania, Hen_US
dc.contributor.authorKolhe, Den_US
dc.contributor.authorKadam, Sen_US
dc.contributor.authorRajput, Jen_US
dc.contributor.authorDevarshi, SPen_US
dc.contributor.authorShaikh, Aen_US
dc.contributor.authorBadani, R.en_US
dc.date.accessioned2025-05-12T09:38:11Z
dc.date.available2025-05-12T09:38:11Z
dc.date.issued2024-12
dc.description.abstractGlobally, hypertension is a major noncommunicable disease that contributes to significant fatalities and morbidity. Evaluation of trends in the prescription of antihypertensives and their adherence to the Joint National Commission 8 (JNC 8) recommendations can provide perspective on the dissemination of local and international guidelines in real-world clinical practice. An ambispective observational study was conducted over a duration of 6 months. Among the three- drug combinations, angiotensin receptor blockers (ARB) + beta-blocker (BB) + calcium channel blocker (CCB) (10%), followed by ARB + CCB + diuretic (DU) (8%), were primarily prescribed. BB + diuretic (DU) (20%) was the most prescribed in two-drug combination therapy, followed by ARB + BB (19%). BB (46%) were the most prescribed drugs, followed by diuretics (25%) as monotherapy. Combination therapy is as efficient as single-drug therapy. Among patients with hypertension and heart failure with reduced ejection fraction (HFrEF), the ARNI/ARB combination is effective in HFrEF patients. ARNI/ARB + antihypertensives were most commonly prescribed (40%), followed by ARNI/ ARB + ivabradine + antihypertensives (35%). Adherence to the JNC 8 guidelines varied between 71 and 92%. Ninety-two percent of the prescriptions were adherent to initiating pharmacological treatment in patients aged over 60 years with a BP goal of <140/90, with thiazide/loop diuretics, CCB, and ACEI/ARB as first-line therapy. The pattern of prescribed drugs was in accordance with clinical guidelines. Compliance with JNC 8 guidelines was optimal. However, studies including larger patient populations, drug dosages used, and physician perspectives on prescribing need to be studied further.en_US
dc.identifier.affiliationsStudent SCES’s Indira College of Pharmacy Pune, Maharashtra, Indiaen_US
dc.identifier.affiliationsStudent SCES’s Indira College of Pharmacy Pune, Maharashtra, Indiaen_US
dc.identifier.affiliationsStudent SCES’s Indira College of Pharmacy Pune, Maharashtra, Indiaen_US
dc.identifier.affiliationsStudent SCES’s Indira College of Pharmacy Pune, Maharashtra, Indiaen_US
dc.identifier.affiliationsAssistant Professor, Department of Pharmacy Practice Maharashtra, Indiaen_US
dc.identifier.affiliationsAssistant Professor, Department of Pharmacy Practice Maharashtra, Indiaen_US
dc.identifier.affiliationsAssistant Professor, Department of Pharmacy Practice Maharashtra, Indiaen_US
dc.identifier.citationDamania H, Kolhe D, Kadam S, Rajput J, Devarshi SP, Shaikh A, Badani R.. Evaluation of Prescription Pattern of Antihypertensives and Its Compliance with Joint National Committee 8 Guidelines in Hospital Setting. Journal of the Association of Physicians of India. 2024 Dec; 72(12): 1-5en_US
dc.identifier.issn0004-5772
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/247355
dc.languageenen_US
dc.publisherJournal of Indian Medical Associationen_US
dc.relation.issuenumber12en_US
dc.relation.volume72en_US
dc.source.urihttps://doi.org/10.59556/japi.72.0760en_US
dc.titleEvaluation of Prescription Pattern of Antihypertensives and Its Compliance with Joint National Committee 8 Guidelines in Hospital Settingen_US
dc.typeJournal Articleen_US
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