Comparative Analysis of the Distribution of Various Subtypes of Lymphoid Malignancies in Uttarakhand with other Regions in India.

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dc.contributor.authorBhardwaj, Aparna
dc.contributor.authorKusum, Anuradha
dc.contributor.authorKishore, Sanjeev
dc.date.accessioned2015-04-13T09:34:09Z
dc.date.available2015-04-13T09:34:09Z
dc.date.issued2012-04
dc.description.abstractLymphoid malignancies (LM) form an umbrella term comprising both Hodgkin Disease (HD) and Non Hodgkin Lymphoma (NHL). A number of studies conducted in India and worldwide suggests that the disease exhibits similar pattern with contrasting regional variations. Examining regional variations is important as it may provide an insight to the etiological factor and pathogenesis of the disease. Aim: The aim of our study was to investigate the current pattern of lymphoid malignancies both HD and NHL in Uttarakhand and subsequently compare the results with other regions. Materials and Methods: We analyzed 116 cases of Lymphoid Malignancies that were reviewed over a period of 18 months. Both HD and NHL were diagnosed morphologically and then Immunohistochemistry (IHC) using CD3, CD15, CD20, CD30, and CD45 was employed to further subtype disease according to current WHO classification. Results: The lymphoid malignancies were further subdivided into HD and NHL. Nodular Sclerosis (NS) was the dominant subtype of HD in Uttarakhand (48.78%) and was comparable with results from other regions. Statistical analysis regarding distribution of various subtypes of HD in Uttarakhand and its comparison with three distinct geographical regions also showed p value < 0.241832 which was not statistically significant. However, amongst NHL Diffuse Large B cell Lymphoma (DLBCL) (54.66%) was the commonest subtype. Besides, a significant number of cases of Anaplastic Large Cell Lymphoma (12%) were also observed. Furthermore, statistical analysis showed that the distribution of various subtypes of NHL in Uttarakhand when compared to three distinct geographical regions was statistically significant (P value < 0.002808). Conclusion: Geographic differences in the incidence and histologic subtypes of Lymphomas do exist.en_US
dc.identifier.citationBhardwaj Aparna, Kusum Anuradha, Kishore Sanjeev. Comparative Analysis of the Distribution of Various Subtypes of Lymphoid Malignancies in Uttarakhand with other Regions in India. Indian Medical Gazette. 2012 Apr ; 145 (4): 147-152.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/157398
dc.language.isoenen_US
dc.source.urihttps://medind.nic.in/ice/t12/i4/icet12i4p147.pdfen_US
dc.subjectImmunohistochemistry (IHC)en_US
dc.subjectLymphoiden_US
dc.subjectmalignanciesen_US
dc.subjectRegionalen_US
dc.subjectUttarakhanden_US
dc.subject.meshAdult
dc.subject.meshFemale
dc.subject.meshGeography
dc.subject.meshHumans
dc.subject.meshIndia --epidemiology
dc.subject.meshLeukemia, Lymphoid --classification
dc.subject.meshLeukemia, Lymphoid --epidemiology
dc.subject.meshLeukemia, Lymphoid --statistics & numerical data
dc.subject.meshLymphatic Diseases --classification
dc.subject.meshLymphatic Diseases --epidemiology
dc.subject.meshLymphatic Diseases --statistics & numerical data
dc.subject.meshMale
dc.subject.meshTreatment Outcome
dc.subject.meshWorld Health Organization
dc.subject.meshYoung Adult
dc.titleComparative Analysis of the Distribution of Various Subtypes of Lymphoid Malignancies in Uttarakhand with other Regions in India.en_US
dc.typeArticleen_US
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