Wound healing property of ethanolic extract of leaves of Hyptis suaveolens with supportive role of antioxidant enzymes.

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dc.contributor.authorShirwaikar, Annieen_US
dc.contributor.authorShenoy, Radhikaen_US
dc.contributor.authorUdupa, A Len_US
dc.contributor.authorUdupa, S Len_US
dc.contributor.authorShetty, Somashekaren_US
dc.date.accessioned2009-05-28T11:19:24Z
dc.date.available2009-05-28T11:19:24Z
dc.date.issued2003-03-23en_US
dc.description.abstractEthanolic extract of leaves of Hyptis suaveolens was evaluated for its wound healing activity in ether-anaesthetized Wistar rats at two different doses (400 and 800 mg/kg) using incision, excision, and dead space wound model. Significant increase in skin breaking strength, granuloma breaking strength, wound contraction, hydroxyproline content and dry granuloma weight and decrease in epithelization period was observed. A supportive study made on granuloma tissue to estimate the levels of catalase and superoxide dismutase recorded a significant increase in the level of these antioxidant enzymes. Granuloma tissue was subjected to histopathological examination to determine the pattern of lay-down for collagen using Van Gieson and Masson Trichrome stains. Enhanced wound healing activity may be due to free radical scavenging action of the plant and enhanced level of antioxidant enzymes in granuloma tissue. Better collagenation may be because of improved antioxidant studies.en_US
dc.description.affiliationDepartment of Pharmacognosy, College of Pharmaceutical Sciences, Manipal 576119, India. annieshirwaikar@yahoo.comen_US
dc.identifier.citationShirwaikar A, Shenoy R, Udupa AL, Udupa SL, Shetty S. Wound healing property of ethanolic extract of leaves of Hyptis suaveolens with supportive role of antioxidant enzymes. Indian Journal of Experimental Biology. 2003 Mar; 41(3): 238-41en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/56554
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntioxidants --metabolismen_US
dc.subject.meshEnzymes --metabolismen_US
dc.subject.meshEthanol --chemistryen_US
dc.subject.meshFemaleen_US
dc.subject.meshHyptis --chemistryen_US
dc.subject.meshMaleen_US
dc.subject.meshPlant Extracts --pharmacologyen_US
dc.subject.meshPlant Leaves --chemistryen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshWound Healing --drug effectsen_US
dc.titleWound healing property of ethanolic extract of leaves of Hyptis suaveolens with supportive role of antioxidant enzymes.en_US
dc.typeJournal Articleen_US
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