Citric acid-glycerol-based NADES for microwave-assisted extraction enhances the polyphenols level of Eleutherine bulbosa mill. Urb. Bulbs

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dc.contributor.authorAhmad, Ien_US
dc.contributor.authorShakti, SOPen_US
dc.contributor.authorPrabowo, WCen_US
dc.contributor.authorHikmawan, BDen_US
dc.contributor.authorArifuddin, Men_US
dc.contributor.authorAngelina, Men_US
dc.contributor.authorPrastya, MEen_US
dc.contributor.authorOkselni, Ten_US
dc.contributor.authorAlwi, RSen_US
dc.contributor.authorSadikin, Ren_US
dc.contributor.authorIswahyudi, Ien_US
dc.contributor.authorFebrina, Len_US
dc.contributor.authorHerman, Hen_US
dc.contributor.authorJunaidin, Jen_US
dc.contributor.authorFaisal, Men_US
dc.contributor.authorSamsul, Een_US
dc.contributor.authorIbrahim, Aen_US
dc.contributor.authorMun’im, Aen_US
dc.date.accessioned2024-11-30T11:21:19Z
dc.date.available2024-11-30T11:21:19Z
dc.date.issued2024-09
dc.description.abstractNatural deep eutectic solvent combined with Microwave-assisted extraction (MAE) is considered as a potential green substitute for conventional extraction methods because of its selectivity and shorter extraction time. Eleutherine bulbosa Mill Urb. (E. bulbosa) bulbs, is renowned for having a high concentration of bioactive substances, primarily phenolics compounds with various therapeutic characteristics. This study aims to increase the level of total phenolics content (TPC) in E. bulbosa bulbs extract by applying a citric acid-glycerol (CA-Gly)-MAE and to optimize its extraction conditions using response surface methodology-based box-behnken design. In this study, we extracted dried samples under various conditions including microwave irradiation time and power, solid–liquid, sample-solvent ratio, and CA-Gly ratio. The measurements of TPC value were done spectrophotometrically and gallic acid was used as standard reference. The recommended optimum conditions were at 50% microwave power for 15 minutes, ratio of 1:14 g/ml, and CA-Gly ratio of 1:1 g/g, resulting in a predicted TPC value of 74.749 ± 3.716 mg GAE/g DW extract. Confirmation experiments were conducted using the recommended optimal extraction parameters, and the obtained TPC value was 84.653 ± 0.918 mg GAE/g DW extract. Our result demonstrates the potential of the CA-Gly-MAE for obtaining a higher yield of polyphenols from E. bulbosa bulbs.en_US
dc.identifier.affiliationsDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia; Pharmaceutical Research and Development Laboratory of FARMAKA TROPIS, Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesiaen_US
dc.identifier.affiliationsDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesiaen_US
dc.identifier.affiliationsPharmaceutical Research and Development Laboratory of FARMAKA TROPIS, Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesiaen_US
dc.identifier.affiliationsPharmaceutical Research and Development Laboratory of FARMAKA TROPIS, Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesiaen_US
dc.identifier.affiliationsPharmaceutical Research and Development Laboratory of FARMAKA TROPIS, Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesiaen_US
dc.identifier.affiliationsResearch Center for Pharmaceutical Ingredients and Traditional Medicine, National Research and Innovation Agency (BRIN), South Tangerang, Indonesiaen_US
dc.identifier.affiliationsResearch Center for Pharmaceutical Ingredients and Traditional Medicine, National Research and Innovation Agency (BRIN), South Tangerang, Indonesiaen_US
dc.identifier.affiliationsResearch Centre for Computing, National Research and Innovation Agency (BRIN), Cibinong, Indonesiaen_US
dc.identifier.affiliationsResearch Centre for Computing, National Research and Innovation Agency (BRIN), Cibinong, Indonesiaen_US
dc.identifier.affiliationsDepartment of Research and Development, PT. Borneo Riseta Naturafarm, Kutai Kertanegara, Indonesiaen_US
dc.identifier.affiliationsPharmaceutical Research and Development Laboratory of FARMAKA TROPIS, Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesiaen_US
dc.identifier.affiliationsPharmaceutical Research and Development Laboratory of FARMAKA TROPIS, Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesiaen_US
dc.identifier.affiliationsPharmaceutical Research and Development Laboratory of FARMAKA TROPIS, Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesiaen_US
dc.identifier.affiliationsPharmaceutical Research and Development Laboratory of FARMAKA TROPIS, Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesiaen_US
dc.identifier.affiliationsPharmaceutical Research and Development Laboratory of FARMAKA TROPIS, Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesiaen_US
dc.identifier.affiliationsPharmaceutical Research and Development Laboratory of FARMAKA TROPIS, Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesiaen_US
dc.identifier.affiliationsLaboratory of Pharmacognosy-Phytochemistry, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia.en_US
dc.identifier.citationAhmad I, Shakti SOP, Prabowo WC, Hikmawan BD, Arifuddin M, Angelina M, Prastya ME, Okselni T, Alwi RS, Sadikin R, Iswahyudi I, Febrina L, Herman H, Junaidin J, Faisal M, Samsul E, Ibrahim A, Mun’im A. Citric acid-glycerol-based NADES for microwave-assisted extraction enhances the polyphenols level of Eleutherine bulbosa mill. Urb. Bulbs. Journal of Applied Pharmaceutical Science. 2024 Sept; 14(9): 189-197en_US
dc.identifier.issn2231-3354
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/237697
dc.languageenen_US
dc.publisherOpen Science Publishers LLPen_US
dc.relation.issuenumber9en_US
dc.relation.volume14en_US
dc.source.urihttps://doi.org/10.7324/JAPS.2024.180291en_US
dc.subjectCitric acid-glycerolen_US
dc.subjectnatural deep eutectic solventen_US
dc.subjectEleutherine bulbosa Mill. Urb. Bulbsen_US
dc.subjectmicrowave- assisted extractionen_US
dc.subjecttotal polyphenols content.en_US
dc.titleCitric acid-glycerol-based NADES for microwave-assisted extraction enhances the polyphenols level of Eleutherine bulbosa mill. Urb. Bulbsen_US
dc.typeJournal Articleen_US
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