Unmet Need for Further LDL-C Lowering in India despite Statin Therapy: Lipid Association of India Recommendations for the Use of Bempedoic Acid

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dc.contributor.authorMehta, Ven_US
dc.contributor.authorPuri, Ren_US
dc.contributor.authorDuell, PBen_US
dc.contributor.authorIyengar, S Sen_US
dc.contributor.authorWong, Nathan, Den_US
dc.contributor.authorYusuf, Jamalen_US
dc.contributor.authorMukhopadhyay, Saibalen_US
dc.contributor.authorPradhan, Akshayaen_US
dc.contributor.authorMuruganathan, Arumugamen_US
dc.contributor.authorWangnoo, S Ken_US
dc.contributor.authorKapoor, Dheerajen_US
dc.contributor.authorRastogi, Ashuen_US
dc.contributor.authorTiwaskar, Mangesh Hen_US
dc.contributor.authorMahajan, Kunalen_US
dc.contributor.authorNarasingan, S Nen_US
dc.contributor.authorAgarwala, Rajeeven_US
dc.contributor.authorBordoloi, Neilen_US
dc.contributor.authorSoumitra, Kumaren_US
dc.contributor.authorChakraborty, Rabinen_US
dc.contributor.authorShetty, Sadananden_US
dc.contributor.authorSaboo, Bansien_US
dc.contributor.authorKhan, Azizen_US
dc.contributor.authorPrabhakar, Den_US
dc.contributor.authorKhanna, Narendra Nathen_US
dc.contributor.authorMehta, Ashwanien_US
dc.contributor.authorBansal, Manishen_US
dc.contributor.authorKasliwal, Ravien_US
dc.contributor.authorMehrotra, Rahulen_US
dc.contributor.authorChag, Milanen_US
dc.contributor.authorSheikh, Altameshen_US
dc.contributor.authorSattur, Gururaj Balvantraoen_US
dc.contributor.authorManoria, P Cen_US
dc.contributor.authorPareek, K Ken_US
dc.contributor.authorPancholia, A Ken_US
dc.contributor.authorMelinkeri, Rashida Patanwalaen_US
dc.contributor.authorNanda, Rashmien_US
dc.contributor.authorKalra, Dineshen_US
dc.date.accessioned2023-06-17T08:20:24Z
dc.date.available2023-06-17T08:20:24Z
dc.date.issued2022-09
dc.description.abstractLipid-lowering therapy plays a crucial role in reducing adverse cardiovascular (CV) events in patients with established atherosclerotic cardiovascular disease (ASCVD) and familial hypercholesterolemia. Lifestyle interventions along with high-intensity statin therapy are the first-line management strategy followed by ezetimibe. Only about 20–30% of patients who are on maximally tolerated statins reach recommended low-density lipoprotein cholesterol (LDL-C) goals. Several factors contribute to the problem, including adherence issues, prescription of less than high-intensity statin therapy, and de-escalation of statin dosages, but in patients with very high baseline LDL-C levels, including those with familial hypercholesterolemia and those who are intolerant to statins, it is critical to expand our arsenal of LDL-C-lowering medications. Moreover, in the extreme risk group of patients with an LDL-C goal of ?30 mg/dL according to the Lipid Association of India (LAI) risk stratification algorithm, there is a significant residual risk requiring the addition of non-statin drugs to achieve LAI recommended targets. This makes bempedoic acid a welcome addition to the existing non-statin therapies such as ezetimibe, bile acid sequestrants, and PCSK9 inhibitors. A low frequency of muscle-related side effects, minimal drug interactions, a significant reduction in high-sensitivity C-reactive protein (hsCRP), and a lower incidence of new-onset or worsening diabetes make it a useful adjunct for LDL-C lowering. However, the CV outcomes trial results are still pending. In this LAI consensus document, we discuss the pharmacology, indications, contraindications, advantages, and evidence-based recommendations for the use of bempedoic acid in clinical practice.en_US
dc.identifier.affiliationsChair, Director-Professor, Department of Cardiology, Govind Ballabh Pant Institute of Postgraduate Medical Education & Research, New Delhien_US
dc.identifier.affiliationsCo-chair, Senior Consultant Cardiologist, Indraprastha Apollo Hospitals, New Delhi, Delhi, Indiaen_US
dc.identifier.affiliationsCo-chair, Professor of Medicine and Director, Cardiovascular Institute and Division of Endocrinology, Diabetes and Clinical Nutrition, Oregon Health & Science University, Portland, Oregon, USAen_US
dc.identifier.affiliationsSr. Consultant, Department of Cardiology, Manipal Hospitals, Bengaluru, Karnataka, Indiaen_US
dc.identifier.affiliationsProfessor and Director, Heart Disease Prevention Program Division of Cardiology, University of California Irvine, Irvine, California, USAen_US
dc.identifier.affiliationsDirector-Professoren_US
dc.identifier.affiliationsDirector-Professor and Head, Department of Cardiology, Govind Ballabh Pant Institute of Postgraduate Medical Education & Research, New Delhi, Delhien_US
dc.identifier.affiliationsSr. Consultant, Department of Cardiology, King George’s Medical University, Lucknow, Uttar Pradeshen_US
dc.identifier.affiliationsSr. Consultant, Department of Internal Medicine, AG Hospital, Tirupur, Tamil Naduen_US
dc.identifier.affiliationsSr. Consultant Endocrinologist & Diabetologist, Indraprastha Apollo Hospitals, New Delhi, Delhien_US
dc.identifier.affiliationsHead, Department of Endocrinology, Artemis Hospital, Gurugram, Haryanaen_US
dc.identifier.affiliationsAssistant Professor, Department of Endocrinology and Metabolism, Postgraduate Institute of Medical Education and Research, Chandigarh, Punjaben_US
dc.identifier.affiliationsConsultant Physician and Dialectologist, Shilpa Medical Research Centre, Mumbai, Maharashtraen_US
dc.identifier.affiliationsAssistant Professor, Department of Cardiology, Indira Gandhi Medical College & Hospital, Shimla, Himachal Pradeshen_US
dc.identifier.affiliationsFormer Adjunct Professor, Department of Medicine, The Tamil Nadu Dr. M.G.R. Medical Universityen_US
dc.identifier.affiliationsManaging Director, SNN Specialities Clinic, Chennai, Tamil Naduen_US
dc.identifier.affiliationsSr. Consultant Cardiologist, Jaswant Rai Speciality Hospital, Meerut, Uttar Pradeshen_US
dc.identifier.affiliationsManaging Director and HOD, Department of Cardiology, Excelcare Hospitals, Guwahati, Assamen_US
dc.identifier.affiliationsProfessor and Head, Department of Cardiology, Vivekananda Institute of Medical Sciences, Kolkata, West Bengalen_US
dc.identifier.affiliationsConsultant Cardiologist, Kokilaben Dhirubhai Ambani Hospital & Medical Research Instituteen_US
dc.identifier.affiliationsDirector, Centre for Cardiac Sciencesen_US
dc.identifier.affiliationsHead, Department of Cardiology, KJ Somaiya Hospital Super Speciality Center, Mumbai, Maharashtraen_US
dc.identifier.affiliationsChief Diabetologist & Chairman, Dia-Care Diabetes Care & Hormone Clinic, Ahmedabad, Gujaraten_US
dc.identifier.affiliationsSr. Consultant Cardiologist, Crescent Hospital & Heart Centre, Nagpur, Maharashtraen_US
dc.identifier.affiliationsSr. Consultant, Department of Cardiology, Apollo Hospitals, Chennai, Tamil Naduen_US
dc.identifier.affiliationsSr. Consultant, Department of Cardiology, Indraprastha Apollo Hospitalsen_US
dc.identifier.affiliationsSr. Consultant Cardiologist, Sir Ganga Ram Hospital, New Delhi, Delhien_US
dc.identifier.affiliationsAssociate Director, Department of Cardiologyen_US
dc.identifier.affiliationsChairman, Division of Clinical & Preventive Cardiology, Medanta Hospital, Gurugram, Haryanaen_US
dc.identifier.affiliationsDirector & Head, Department of Non-invasive Cardiology, Max Super Speciality Hospital, New Delhi, Delhien_US
dc.identifier.affiliationsInterventional Cardiologist & Managing Director, Marengo CIMS, Ahmedabad, Gujaraten_US
dc.identifier.affiliationsSr. Consultant, Department of Endocrinology, Saifee Hospital, Mumbai, Maharashtraen_US
dc.identifier.affiliationsSr. Consultant Physician and Diabetologist, Sattur Medical Care, Hubli, Karnatakaen_US
dc.identifier.affiliationsDirector, Manoria Heart and Critical Care Hospital, Bhopal, Madhya Pradeshen_US
dc.identifier.affiliationsHead, Department of Medicine, S. N. Pareek Hospital, Kota, Rajasthanen_US
dc.identifier.affiliationsHead of Department, Department of Medicine & Preventive Cardiology, Arihant Hospital & Research Centre, Indore, Madhya Pradeshen_US
dc.identifier.affiliationsSr. Consultant, Department of Internal Medicine, Sahyadri Hospitals, Pune, Maharashtraen_US
dc.identifier.affiliationsConsultant Physician, Cardiac Care Centre, New Delhi, Delhi, Indiaen_US
dc.identifier.affiliationsAssociate Professor, Department of Medicine, Rush Medical College, Rush Medical College, USAen_US
dc.identifier.citationMehta V, Puri R, Duell PB, Iyengar S S, Wong Nathan D, Yusuf Jamal, Mukhopadhyay Saibal, Pradhan Akshaya, Muruganathan Arumugam, Wangnoo S K, Kapoor Dheeraj, Rastogi Ashu, Tiwaskar Mangesh H, Mahajan Kunal, Narasingan S N, Agarwala Rajeev, Bordoloi Neil, Soumitra Kumar, Chakraborty Rabin, Shetty Sadanand, Saboo Bansi, Khan Aziz, Prabhakar D, Khanna Narendra Nath, Mehta Ashwani, Bansal Manish, Kasliwal Ravi, Mehrotra Rahul, Chag Milan, Sheikh Altamesh, Sattur Gururaj Balvantrao, Manoria P C, Pareek K K, Pancholia A K, Melinkeri Rashida Patanwala, Nanda Rashmi, Kalra Dinesh. Unmet Need for Further LDL-C Lowering in India despite Statin Therapy: Lipid Association of India Recommendations for the Use of Bempedoic Acid. Journal of the Association of Physicians of India. 2022 Sep; 70(9): 67-75en_US
dc.identifier.issn0004 – 5772
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/216256
dc.languageenen_US
dc.publisherAssociation of Physicians of Indiaen_US
dc.relation.issuenumber9en_US
dc.relation.volume70en_US
dc.source.urihttps://doi.org/10.5005/japi-11001-0099en_US
dc.titleUnmet Need for Further LDL-C Lowering in India despite Statin Therapy: Lipid Association of India Recommendations for the Use of Bempedoic Aciden_US
dc.typeJournal Articleen_US
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