Cardiovascular Changes in Hypothyroidism, a Tertiary Centre Study

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dc.contributor.authorShakir, Saad Mohammaden_US
dc.contributor.authorSingh, Vinod Kumaren_US
dc.date.accessioned2020-01-02T07:21:59Z
dc.date.available2020-01-02T07:21:59Z
dc.date.issued2018-07
dc.description.abstractBackground:Among the commonly existing endocrine disorders found in India, Thyroid disease contributes fairly to the clinical scenario affecting around 9-15 % of the female population as well as the male population to a milder degree. Among the principal targets of the thyroid hormones is the cardiovascular system. The effects noted on the CVS are changes in the cardiac contractility, myocardial oxygen consumption, alterations in the systemic vascular resistance (SVR), decreased cardiac contractility leading to decreased cardiac output, increased rate of atherosclerosis and hence greater potential of CAD. Hypothyroidism also causes QT interval prolongation. Only few studies have been done in our country to assess these cardiovascular parameters in hypothyroid patients. Principally the thyroid hormone-T3, affects the heart with variations in cardiac gene expression principally mediated by T3. On 2D-ECHO mild Left Ventricular Diastolic Dysfunction (LVDD), mild concentric Left Ventricular Hypertrophy (LVH) with or without Left Ventricular Diastolic Dysfunction, mild mitral insufficiency or minimal pericardial effusion can be found. Since there does exist some evidence of a causal relationship, it is advisable to perform a basic cardiac work-up which should also include an echocardiogram to assess systolic and diastolic dysfunction as part of initial evaluation of the hypothyroid patients. Also to make note is the fact that persistent subclinical thyroid dysfunction may notably increase the cardiovascular disease risk ratio.en_US
dc.identifier.affiliationsPost Graduate, department of Medicine, TMMC&RC, Moradabad, Uttar Pradesh, India.en_US
dc.identifier.affiliationsProfessor & Head, Department of Medicine, TMMC&RC, Moradabad, Uttar Pradesh, India.en_US
dc.identifier.citationShakir Saad Mohammad, Singh Vinod Kumar. Cardiovascular Changes in Hypothyroidism, a Tertiary Centre Study. Annals of International medical and Dental Research. 2018 Jul; 4(4): 9-14en_US
dc.identifier.issn2395-2822
dc.identifier.issn2395-2814
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/192681
dc.languageenen_US
dc.publisherSociety for Health Care & Research Developmenten_US
dc.relation.issuenumber4en_US
dc.relation.volume4en_US
dc.source.urihttps://doi.org/10.21276/aimdr.2018.4.4.ME2en_US
dc.titleCardiovascular Changes in Hypothyroidism, a Tertiary Centre Studyen_US
dc.typeJournal Articleen_US
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