Acyclovir susceptibility of herpes simplex virus isolates at King Chulalongkorn Memorial Hospital, Bangkok.

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dc.contributor.authorSangdara, Ajchariyaraten_US
dc.contributor.authorBhattarakosol, Parvapanen_US
dc.date.accessioned2009-05-27T21:45:31Z
dc.date.available2009-05-27T21:45:31Z
dc.date.issued2008-06-14en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractOBJECTIVE: To determine the ACV susceptibility in Thai HSV clinical isolates. MATERIAL AND METHOD: One hundred thirty HSV isolates from the Virology Laboratory Unit, King Chulalongkorn Memorial Hospital, Bangkok Thailand had typing done by immunofluoresent assay using monoclonal antibody specific to either HSV-1 or HSV-2. Their sensitivity to ACV (IC50) was determined by plaque reduction assay. RESULTS: The IC50 of 77 HSV-1 isolates ranged from 0.07-0.97 microg/ml and that of 53 HSV-2 isolates was 0.13-1.66 microg/ml. The standard HSV-1 (KOS) and HSV-2 (Baylor 186) were included in each run. The mean + standard deviation (SD) of ACV IC50 among HSV-1 and HSV-2 isolates were 0.38 +/- 0.23 and 0.50 +/- 0.32 microg/ml while that of standard HSV-1 and HSV-2 were 0.45 +/- 0.13 and 0.57 +/- 0.04 microg/ml. Statistically significant difference between IC50 of HSV-1 and HSV-2 isolates was indicated (p = 0.02). CONCLUSION: No ACV(r) HSV has been detected and ACV susceptibility of HSV-2 has more resistance than that of HSV-1.en_US
dc.description.affiliationInter-department of Medical Microbiology, Faculty ofGraduate School, Chulalongkorn University, Bangkok, Thailand.en_US
dc.identifier.citationSangdara A, Bhattarakosol P. Acyclovir susceptibility of herpes simplex virus isolates at King Chulalongkorn Memorial Hospital, Bangkok. Journal of the Medical Association of Thailand. 2008 Jun; 91(6): 908-12en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/45351
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAcyclovir --therapeutic useen_US
dc.subject.meshAntiviral Agents --therapeutic useen_US
dc.subject.meshDisease Susceptibilityen_US
dc.subject.meshFemaleen_US
dc.subject.meshFluorescent Antibody Technique, Directen_US
dc.subject.meshHerpesvirus 1, Human --drug effectsen_US
dc.subject.meshHerpesvirus 2, Human --drug effectsen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshPilot Projectsen_US
dc.subject.meshSensitivity and Specificityen_US
dc.subject.meshThailanden_US
dc.titleAcyclovir susceptibility of herpes simplex virus isolates at King Chulalongkorn Memorial Hospital, Bangkok.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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