Acyclovir susceptibility of herpes simplex virus isolates at King Chulalongkorn Memorial Hospital, Bangkok.
dc.contributor.author | Sangdara, Ajchariyarat | en_US |
dc.contributor.author | Bhattarakosol, Parvapan | en_US |
dc.date.accessioned | 2009-05-27T21:45:31Z | |
dc.date.available | 2009-05-27T21:45:31Z | |
dc.date.issued | 2008-06-14 | en_US |
dc.description | Chotmaihet Thangphaet. | en_US |
dc.description.abstract | OBJECTIVE: To determine the ACV susceptibility in Thai HSV clinical isolates. MATERIAL AND METHOD: One hundred thirty HSV isolates from the Virology Laboratory Unit, King Chulalongkorn Memorial Hospital, Bangkok Thailand had typing done by immunofluoresent assay using monoclonal antibody specific to either HSV-1 or HSV-2. Their sensitivity to ACV (IC50) was determined by plaque reduction assay. RESULTS: The IC50 of 77 HSV-1 isolates ranged from 0.07-0.97 microg/ml and that of 53 HSV-2 isolates was 0.13-1.66 microg/ml. The standard HSV-1 (KOS) and HSV-2 (Baylor 186) were included in each run. The mean + standard deviation (SD) of ACV IC50 among HSV-1 and HSV-2 isolates were 0.38 +/- 0.23 and 0.50 +/- 0.32 microg/ml while that of standard HSV-1 and HSV-2 were 0.45 +/- 0.13 and 0.57 +/- 0.04 microg/ml. Statistically significant difference between IC50 of HSV-1 and HSV-2 isolates was indicated (p = 0.02). CONCLUSION: No ACV(r) HSV has been detected and ACV susceptibility of HSV-2 has more resistance than that of HSV-1. | en_US |
dc.description.affiliation | Inter-department of Medical Microbiology, Faculty ofGraduate School, Chulalongkorn University, Bangkok, Thailand. | en_US |
dc.identifier.citation | Sangdara A, Bhattarakosol P. Acyclovir susceptibility of herpes simplex virus isolates at King Chulalongkorn Memorial Hospital, Bangkok. Journal of the Medical Association of Thailand. 2008 Jun; 91(6): 908-12 | en_US |
dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/45351 | |
dc.language.iso | eng | en_US |
dc.source.uri | https://www.mat.or.th/journal/all.php | en_US |
dc.subject.mesh | Acyclovir --therapeutic use | en_US |
dc.subject.mesh | Antiviral Agents --therapeutic use | en_US |
dc.subject.mesh | Disease Susceptibility | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Fluorescent Antibody Technique, Direct | en_US |
dc.subject.mesh | Herpesvirus 1, Human --drug effects | en_US |
dc.subject.mesh | Herpesvirus 2, Human --drug effects | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Pilot Projects | en_US |
dc.subject.mesh | Sensitivity and Specificity | en_US |
dc.subject.mesh | Thailand | en_US |
dc.title | Acyclovir susceptibility of herpes simplex virus isolates at King Chulalongkorn Memorial Hospital, Bangkok. | en_US |
dc.type | Journal Article | en_US |
dc.type | Research Support, Non-U.S. Gov't | en_US |
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