The Effectiveness Of Selective Stem Cell Placement On Gait Performance In Patients With Multiple Sclerosis: A Phase I Clinical Trial

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dc.contributor.authorCohen, D. S.en_US
dc.contributor.authorBroeska, Hen_US
dc.date.accessioned2020-10-16T07:49:51Z
dc.date.accessioned2024-09-24T11:51:23Z
dc.date.available2020-10-16T07:49:51Z
dc.date.available2024-09-24T11:51:23Z
dc.date.issued2019-05
dc.description.abstractThis report describes a Phase I clinical trial of a novel selective stem cell placement (SSCP) protocol using autologous bone marrow mononuclear stem cells (BM-MNSCs) to treat patients with multiple sclerosis (MS) with post-operative functional changes measured by gait performance. Previous studies have demonstrated that clinically significant gait deviations occur at all stages of MS that involve walking. Consequently, to determine the functional benefit of SSCP, the timed 25-foot walk (T25FW) was administered to 31 MS patients before and after treatment. The time and number of steps taken to complete the test significantly decreased post-intervention. This suggests that recovery of function in MS patients is possible and that SSCP using BM-MNSCs should be considered for future clinical trials as a possible treatment for MS. Study limitations and directions for future research are also discussed.en_US
dc.identifier.affiliationsSchool of Medicine, University of Massachusetts, Boston, USAen_US
dc.identifier.affiliationsSaddleback College, California, USAen_US
dc.identifier.citationCohen D. S., Broeska H. The Effectiveness Of Selective Stem Cell Placement On Gait Performance In Patients With Multiple Sclerosis: A Phase I Clinical Trial. International Journal of Pharmaceutical Sciences and Drug Research. 2019 May; 11(3): 71-77en_US
dc.identifier.issn0975-248X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/206225
dc.languageenen_US
dc.publisherMRI Publication Pvt. Ltd.en_US
dc.relation.issuenumber3en_US
dc.relation.volume11en_US
dc.source.urihttps://doi.org/10.25004/IJPSDR.2019.110301en_US
dc.subjectMultiple Sclerosis – Stem Cells – Trial – Gait – Bone Marrowen_US
dc.titleThe Effectiveness Of Selective Stem Cell Placement On Gait Performance In Patients With Multiple Sclerosis: A Phase I Clinical Trialen_US
dc.typeJournal Articleen_US
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