Functional characterization of intestinal intraepithelium & lamina propria lymphocytes from Giardia lamblia infected mice.

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dc.contributor.authorVinayak, V Ken_US
dc.contributor.authorKhanna, Ren_US
dc.contributor.authorKum, Ken_US
dc.contributor.authorNain, C Ken_US
dc.date.accessioned1989-07-01en_US
dc.date.accessioned2009-05-27T06:46:45Z
dc.date.available1989-07-01en_US
dc.date.available2009-05-27T06:46:45Z
dc.date.issued1989-07-01en_US
dc.description.abstractQuantitation of T cell subsets in intraepithelium and lamina propria during the course of experimental G. lamblia infection in the inbred mice revealed increased influx of Thy 1.2+ (T cells) and Lyt 2.2+ (suppressor/cytotoxic T cells) during the establishment (3-5 day post-inoculation) and acute (9-11 day post-inoculation) phases of infection. The influx of these cells reduced as the parasite load declined. In contrast, no significant changes were noticed in lamina propria and intraepithelium Lyt 1.1+ (helper T cell) cells during the establishment or acute phase but such cells increased significantly in the decline (17-21 day post-inoculation) phase of infection. Further, both intraepithelium and lamina propria lymphocytes isolated from uninfected or infected animals failed to kill G. lamblia trophozoites in vitro in the absence or presence of antigiardial antibodies. Our data suggest that the clearance of G. lamblia trophozoites was not mediated by cytotoxic T cells. However, the induction of helper T cells during the declining phase of infection might be an important mechanism for the induction of parasite specific antibody response leading to the immune elimination of G. lamblia trophozoites from the gut.en_US
dc.identifier.citationVinayak VK, Khanna R, Kum K, Nain CK. Functional characterization of intestinal intraepithelium & lamina propria lymphocytes from Giardia lamblia infected mice. Indian Journal of Medical Research. 1989 Jul; 89(): 271-81en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/17869
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCytotoxicity, Immunologicen_US
dc.subject.meshEpithelium --immunologyen_US
dc.subject.meshGiardiasis --immunologyen_US
dc.subject.meshIntestine, Small --immunologyen_US
dc.subject.meshLeukocyte Counten_US
dc.subject.meshMiceen_US
dc.subject.meshT-Lymphocytes --immunologyen_US
dc.subject.meshT-Lymphocytes, Cytotoxic --immunologyen_US
dc.titleFunctional characterization of intestinal intraepithelium & lamina propria lymphocytes from Giardia lamblia infected mice.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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