Effectiveness of 400 or 600 micrograms of vaginal misoprostol for terminations of early pregnancies.

Simple item page
dc.contributor.authorRuangchainikhom, Wiboolen_US
dc.contributor.authorPhongphissanou, Ekkarachen_US
dc.contributor.authorBhekasuta, Jamikornen_US
dc.contributor.authorSarapak, Sravoothen_US
dc.date.accessioned2009-05-27T21:27:07Z
dc.date.available2009-05-27T21:27:07Z
dc.date.issued2006-07-03en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractOBJECTIVES: To compare the effectiveness and side effects of transvaginal application of 400 or 600 ug of misoprostol for termination of pregnancy. STUDY DESIGN: A prospective randomized single-blinded trial. SETTING: Department of Obstetrics & Gynecology, Bhumibol Adulyadej Hospital. MATERIAL AND METHOD: One-hundred-and-twenty-five pregnant women with less than 20 weeks gestational, at Bhumibol Adulyadej Hospital from June 1, 2003 to May 31, 2004 were recruited. The termination of pregnancy had been suggested by the obstetrician and the decision was made by the patient and her husband. The samples were randomized into 2 groups. Group 1 had 65 patients and 400 ug of misoprostol was applied three times in a 6 hour interval. Group 2 had 60 patients and 600 ug of misoprostol was applied in the same manner. Both groups were observed and evaluated within 24 hours. MAIN OUTCOME MEASURES: Rate of complete abortion and side effects of both 400 and 600 microg misoprostol within 24 hours. RESULTS: No statistical significant difference was found in the general characteristics of both sample groups. Group 1 had an abortion rate of 38.3% while group 2 had an abortion rate of 56.92%. This was statistically significant (p < 0.05). The time interval after insertion to complete abortion was 9.15 +/- 6.09 hours in group 1 and 8.85 +/- 4.68 hours in group 2. Side effects, such as fever, lower abdominal pain, massive vaginal bleeding and diarrhea showed no statistical difference (p > 0.05). CONCLUSION: Transvaginal application of 600 ug misoprostol (3 times every 6 hours) caused a higher rate of complete abortion compared with an application of 400 ug misoprostol. The side effect of both groups showed no statistical difference.en_US
dc.description.affiliationDepartment of Obstetrics and Gynecology, Bhumibol Adulyadej Hospital, Bangkok, Thailand.en_US
dc.identifier.citationRuangchainikhom W, Phongphissanou E, Bhekasuta J, Sarapak S. Effectiveness of 400 or 600 micrograms of vaginal misoprostol for terminations of early pregnancies. Journal of the Medical Association of Thailand. 2006 Jul; 89(7): 928-33en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/44813
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAbortifacient Agents, Nonsteroidal --administration & dosageen_US
dc.subject.meshAbortion, Induceden_US
dc.subject.meshAdministration, Intravaginalen_US
dc.subject.meshAdulten_US
dc.subject.meshChi-Square Distributionen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMisoprostol --administration & dosageen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPregnancy Trimester, Firsten_US
dc.subject.meshPregnancy Trimester, Seconden_US
dc.subject.meshProspective Studiesen_US
dc.titleEffectiveness of 400 or 600 micrograms of vaginal misoprostol for terminations of early pregnancies.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Journal of the Medical Association of Thailand